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dc.contributor.authorGonzález Cano, Rafael 
dc.contributor.authorRuiz Cantero, María del Carmen 
dc.contributor.authorSantos Caballero, Miriam 
dc.contributor.authorGómez Navas, Carlos 
dc.contributor.authorNieto López, Francisco Rafael 
dc.date.accessioned2021-09-21T06:58:48Z
dc.date.available2021-09-21T06:58:48Z
dc.date.issued2021-07-12
dc.identifier.citationGonzález-Cano, R... [et al.]. Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief? Toxins 2021, 13, 483. [https://doi.org/10.3390/toxins13070483]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/70310
dc.descriptionThis publication was partially supported by grant CTS 109 from the Junta de Andalucia, grant INTRAIBS-2020-09 from Biosanitary Research Institute ibs.GRANADA, and grant PPJIA2020-06 from the University of Granada.es_ES
dc.description.abstractTetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels. VGSCs play a key role in pain signaling and some TTX-sensitive VGSCs are highly expressed by adult primary sensory neurons. During pathological pain conditions, such as neuropathic pain, upregulation of some TTX-sensitive VGSCs, including the massive re-expression of the embryonic VGSC subtype NaV1.3 in adult primary sensory neurons, contribute to painful hypersensitization. In addition, people with loss-of-function mutations in the VGSC subtype NaV1.7 present congenital insensitive to pain. TTX displays a prominent analgesic effect in several models of neuropathic pain in rodents. According to this promising preclinical evidence, TTX is currently under clinical development for chemo-therapy-induced neuropathic pain and cancer-related pain. This review focuses primarily on the preclinical and clinical evidence that support a potential analgesic role for TTX in these pain states. In addition, we also analyze the main toxic effects that this neurotoxin produces when it is administered at therapeutic doses, and the therapeutic potential to alleviate neuropathic pain of other natural toxins that selectively block TTX-sensitive VGSCs.es_ES
dc.description.sponsorshipJunta de Andalucia CTS 109es_ES
dc.description.sponsorshipBiosanitary Research Institute ibs.GRANADA INTRAIBS-2020-09es_ES
dc.description.sponsorshipUniversity of Granada PPJIA2020-06es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectTetrodotoxines_ES
dc.subjectTTXes_ES
dc.subjectVoltage-gated sodium channelses_ES
dc.subjectNeuropathic paines_ES
dc.subjectCancer pain es_ES
dc.titleTetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/toxins13070483
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España