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dc.contributor.authorSánchez Diaz, Manuel
dc.contributor.authorQuiñones Vico, María Isabel 
dc.contributor.authorSanabria de la Torre, Raquel 
dc.contributor.authorMontero Vílchez, Trinidad
dc.contributor.authorSierra Sánchez, Álvaro
dc.contributor.authorMolina Leyva, Alejandro 
dc.contributor.authorArias Santiago, Salvador Antonio
dc.identifier.citationSanchez-Diaz, M... [et al.]. Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review. J. Clin. Med. 2021, 10, 2925. []es_ES
dc.descriptionThis research has received competitive funding in the call for grants for the financing of Research, Development and Innovation in Biomedicine and Health Sciences in Andalusia, for the year 2019 (PIGE-0247-2019; PIGE-0242-2019).es_ES
dc.description.abstractMesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this review is to describe how MSCs are distributed after injection, using different administration routes in animal models and humans. A literature search was performed in order to consider how MSCs distribute after intravenous, intraarterial, intramuscular, intraarticular and intralesional injection into both animal models and humans. Studies addressing the biodistribution of MSCs in “in vivo” animal models and humans were included. After the search, 109 articles were included in the review. Intravenous administration of MSCs is widely used; it leads to an initial accumulation of cells in the lungs with later redistribution to the liver, spleen and kidneys. Intraarterial infusion bypasses the lungs, so MSCs distribute widely throughout the rest of the body. Intramuscular, intraarticular and intradermal administration lack systemic biodistribution. Injection into various specific organs is also described. Biodistribution of MSCs in animal models and humans appears to be similar and depends on the route of administration. More studies with standardized protocols of MSC administration could be useful in order to make results homogeneous and more comparable.es_ES
dc.description.sponsorshipResearch, Development and Innovation in Biomedicine and Health Sciences in Andalusia PIGE-0247-2019 PIGE-0242-2019es_ES
dc.rightsAtribución 3.0 España*
dc.subjectMesenchymal stromal celles_ES
dc.subjectCell therapyes_ES
dc.titleBiodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Reviewes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España