EEGs Disclose Significant Brain Activity Correlated with Synaptic Fickleness
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EEG time seriesSynaptic plasticityModulations and explosive transitions in brain waves
Pretel, J.; Torres, J.J.; Marro, J. EEGs Disclose Significant Brain Activity Correlated with Synaptic Fickleness. Biology 2021, 10, 647. https://doi.org/10.3390/biology 10070647
SponsorshipSpanish Ministry of Science and Technology; Agencia Española de Investigación (AEI); FEDER - FIS2017-84256-P; Consejería de Conocimiento, Investigación Universidad, Junta de Andalucía and European Regional Development Funds, Spain - SOMM17/6105/UGR Y A-FQM-175-UGR18; Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía and European Regional Development Funds, Ref. P20_00173
We here study a network of synaptic relations mingling excitatory and inhibitory neuron nodes that displays oscillations quite similar to electroencephalogram (EEG) brain waves, and identify abrupt variations brought about by swift synaptic mediations. We thus conclude that corresponding changes in EEG series surely come from the slowdown of the activity in neuron populations due to synaptic restrictions. The latter happens to generate an imbalance between excitation and inhibition causing a quick explosive increase of excitatory activity, which turns out to be a (first-order) transition among dynamic mental phases. Moreover, near this phase transition, our model system exhibits waves with a strong component in the so-called delta-theta domain that coexist with fast oscillations. These findings provide a simple explanation for the observed delta-gamma and theta-gamma modulation in actual brains, and open a serious and versatile path to understand deeply large amounts of apparently erratic, easily accessible brain data.