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dc.contributor.authorHerrera Quintana, Lourdes María 
dc.contributor.authorGamarra Morales, Yenifer
dc.contributor.authorVázquez Lorente, Héctor 
dc.contributor.authorMolina López, Jorge
dc.contributor.authorCastaño Pérez, José
dc.contributor.authorMachado Casas, Juan Francisco
dc.contributor.authorCoca Zúñiga, Ramón
dc.contributor.authorPérez Villares, José Miguel
dc.contributor.authorPlanells Del Pozo, Elena María 
dc.date.accessioned2021-07-08T08:20:17Z
dc.date.available2021-07-08T08:20:17Z
dc.date.issued2021
dc.identifier.citationHerrera‐Quintana, L.; Gamarra‐Morales, Y.; Vázquez‐Lorente, H.; Molina‐López, J.; Castaño‐Pérez, J.; Machado‐Casas, J.F.; Coca‐Zúñiga, R.; Pérez‐Villares, J.M.; Planells, E. Bad Prognosis in Critical Ill Patients with COVID‐19 during Short‐Term ICU Stay Regarding Vitamin D Levels. Nutrients 2021, 13, 1988. https://doi.org/10.3390/nu13061988es_ES
dc.identifier.urihttp://hdl.handle.net/10481/69603
dc.description.abstractBackground and aims: Vitamin D inadequacy may be involved in the mechanisms of SARS‐CoV‐2 infection and in potential risk factors for disease propagation or control of coronavirus disease 2019 (COVID‐19). This study assessed a short‐term evolution of vitamin D status and its influence upon different clinical parameters in critically ill patients with COVID‐19. Methods: A prospective analytical study in which 37 critically ill volunteers between 41 and 71 years of age with COVID‐19 were evaluated at baseline and three days of intensive care unit (ICU) stay. 25‐OH‐D3 and 25‐OH‐D2 were analyzed by liquid chromatography–tandem mass spectrometry and total 25‐ OH‐D levels were calculated as the sum of both. Results: All patients presented low 25‐OH‐D levels at baseline, decreasing total 25‐OH‐D (p = 0.011) mainly through 25‐OH‐D2 (p = 0.006) levels during ICU stay. 25‐OH‐D2 levels decreased a mean of 41.6% ± 89.6% versus 7.0% ± 23.4% for the 25‐OH‐ D3 form during the ICU stay. Patients who did not need invasive mechanical ventilation presented higher levels of 25‐OH‐D2 at baseline and follow‐up. Lower 25‐OH‐D and 25‐OH‐D3 levels were associated with higher D‐dimer at baseline (p = 0.003; p = 0.001) and at follow up (p = 0.029), higher procalcitonin levels (p = 0.002; p = 0.018) at follow up, and lower percentage lymphocyte counts (p = 0.044; p = 0.040) during ICU stay. Conclusions: Deficient vitamin D status in critical patients was established at the admission and further worsened after three days of stay. Lower vitamin D levels were related to key altered clinical and biochemical parameters on patients with SARS‐CoV‐2 infec‐ tion. Given the different response of the 25‐OH‐D3 and 25‐OH‐D2 forms, it would be useful to mon‐ itor them on the evolution of the critically ill patient.es_ES
dc.description.sponsorshipFIS Projects from Carlos III Health Institute [REF. PI10/1993]es_ES
dc.description.sponsorshipSpanish Ministry of Educationes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectCoronavirus disease 2019es_ES
dc.subjectSARS‐CoV‐2es_ES
dc.subjectVitamin D es_ES
dc.subjectCritical carees_ES
dc.subjectIntensive care patientes_ES
dc.titleBad Prognosis in Critical Ill Patients with COVID‐19 during Short‐Term ICU Stay Regarding Vitamin D Levelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu13061988


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