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dc.contributor.authorTeso Pérez, Claudia 
dc.contributor.authorMartínez Bueno, Manuel 
dc.contributor.authorPeralta Sánchez, Juan Manuel
dc.contributor.authorValdivia Martínez, Dolores Eva 
dc.contributor.authorMaqueda Abreu, Mercedes 
dc.contributor.authorFarez Vidal, María Esther 
dc.contributor.authorMartín Platero, Antonio Manuel 
dc.date.accessioned2021-07-06T10:32:48Z
dc.date.available2021-07-06T10:32:48Z
dc.date.issued2021
dc.identifier.citationTeso-Pérez, C.; Martínez-Bueno, M.; Peralta-Sánchez, J.M.; Valdivia, E.; Maqueda, M.; Fárez-Vidal, M.E.; Martín-Platero, A.M. Enterocin Cross-Resistance Mediated by ABC Transport Systems. Microorganisms 2021, 9, 1411. https://doi.org/10.3390/ microorganisms9071411es_ES
dc.identifier.urihttp://hdl.handle.net/10481/69547
dc.description.abstractIn their struggle for life, bacteria frequently produce antagonistic substances against competitors. Antimicrobial peptides produced by bacteria (known as bacteriocins) are active against other bacteria, but harmless to their producer due to an associated immunity gene that prevents selfinhibition. However, knowledge of cross-resistance between different types of bacteriocin producer remains very limited. The immune function of certain bacteriocins produced by the Enterococcus genus (known as enterocins) is mediated by an ABC transporter. This is the case for enterocin AS-48, a gene cluster that includes two ABC transporter-like systems (Transporter-1 and 2) and an immunity protein. Transporter-2 in this cluster shows a high similarity to the ABC transporter-like system in MR10A and MR10B enterocin gene clusters. The aim of our study was to determine the possible role of this ABC transporter in cross-resistance between these two different types of enterocin. To this end, we designed different mutants (Tn5 derivative and deletion mutants) of the as-48 gene cluster in Enterococcus faecalis and cloned them into the pAM401 shuttle vector. Antimicrobial activity assays showed that enterocin AS-48 Transporter-2 is responsible for cross-resistance between AS-48 and MR10A/B enterocin producers and allowed identification of the MR10A/B immunity gene system. These findings open the way to the investigation of resistance beyond homologous bacteriocins.es_ES
dc.description.sponsorshipJunta de Andalucía (Programa Operativo FEDER Andalucía 2014–2020), grant number A-BIO-083-UGR18es_ES
dc.description.sponsorshipPlan Estatal de Garantía Juvenil (Fondo Social Europeo, Gobierno de España, Ref. PEJ2018-003019-A)es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectEnterocines_ES
dc.subjectABC transporteres_ES
dc.subjectBacteriocin immunityes_ES
dc.subjectMR10A/Bes_ES
dc.subjectAS-48es_ES
dc.titleEnterocin Cross-Resistance Mediated by ABC Transport Systemses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.3390/microorganisms9071411


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