Infrared-Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia
Metadatos
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Wiley-VCH Verlag GmbH
Materia
In vivo imaging Luminescence thermometry Magnetic hyperthermia Near-infrared fluorescence Silver sulfide nanoparticles
Fecha
2021-06-12Referencia bibliográfica
Ximendes, E... [et al.]. Infrared-Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia. Adv. Mater. 2021, 2100077. [https://doi.org/10.1002/adma.202100077]
Patrocinador
Ministerio de Ciencia, Innovacion y Universidades PID2019-106301RB-I00 PID2019-105195RA-I00; Spanish Ministry of Economy and Competitiveness MAT2017-85617-R SEV-2016-0686; Comunidad de Madrid (RENIM-CM - European Structural and Investment Fund) B2017/BMD-3867 NANOMAGCOST-CM P2018/NMT-4321; Spanish Scientific Network HiperNano RED2018-102626-T; European Commission Horizon 2020 project NanoTBTech 801305; CAM PEJ-2018-AI/IND-11245; Comunidad de Madrid 2019-T1/IND-14014; Juan de la Cierva Formacion scholarship FJC2018-036734-I; European Commission through the European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie Grant 797945; Juan de la Cierva Incorporacion scholarship IJC2019-041915-I; Comunidad de Madrid 2018-T1/IND-1005; AECC (Ideas Semilla 2019 project); European COST Action (MyWave) CA17115; European COST Action (Nano2Clinic) CA17140Resumen
Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging the capability of some species to convert the absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses magnetic nanoparticles (MNPs) that can effectively dissipate the energy absorbed under alternating magnetic fields. However, MNPs fail to provide real-time thermal feedback with the risk of unwanted overheating and impeding on-the-fly adjustment of the therapeutic parameters. Localization of MNPs within a tissue in an accurate, rapid, and cost-effective way represents another challenge for increasing the efficacy of MHT. In this work, MNPs are combined with state-of-the-art infrared luminescent nanothermometers (LNTh; Ag2S nanoparticles) in a nanocapsule that simultaneously overcomes these limitations. The novel optomagnetic nanocapsule acts as multimodal contrast agents for different imaging techniques (magnetic resonance, photoacoustic and near-infrared fluorescence imaging, optical and X-ray computed tomography). Most crucially, these nanocapsules provide accurate (0.2 degrees C resolution) and real-time subcutaneous thermal feedback during in vivo MHT, also enabling the attainment of thermal maps of the area of interest. These findings are a milestone on the road toward controlled magnetothermal therapies with minimal side effects.