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dc.contributor.authorVan Puyvelde, Heleen
dc.contributor.authorSánchez Pérez, María José
dc.identifier.citationVan Puyvelde, H.; Papadimitriou, N.; Clasen, J.; Muller, D.; Biessy, C.; Ferrari, P.; Halkjær, J.; Overvad, K.; Tjønneland, A.; Fortner, R.T.; et al. Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Nutrients 2021, 13, 1843. nu13061843es_ES
dc.descriptionWe thank the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, for their contribution to, and ongoing support of, the EPIC Study. We thank Aude De Bruycker for her graphical support.es_ES
dc.description.abstract(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992–2000 and December 2013–December 2015. Dietary MGD intakes were estimated at baseline through foodfrequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.es_ES
dc.description.sponsorshipResearch Foundation Flanders (FWO, 189019N)es_ES
dc.description.sponsorshipResearch Foundation Flanders (FWO, V427019N)es_ES
dc.description.sponsorshipInternational Agency for Research on Cancer (IARC)es_ES
dc.description.sponsorshipDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College Londones_ES
dc.description.sponsorshipNIHR Imperial Biomedical Research Center (BRC)es_ES
dc.description.sponsorshipDanish Cancer Society (Denmark)es_ES
dc.description.sponsorshipLigue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France)es_ES
dc.description.sponsorshipGerman Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany)es_ES
dc.description.sponsorshipAssociazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy)es_ES
dc.description.sponsorshipDutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands)es_ES
dc.description.sponsorshipHealth Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain)es_ES
dc.description.sponsorshipSwedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden)es_ES
dc.description.sponsorshipCancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford), (United Kingdom)es_ES
dc.rightsAtribución 3.0 España*
dc.subjectBreast canceres_ES
dc.titleDietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)es_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España