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dc.contributor.authorGómez Hernández, Gonzalo
dc.contributor.authorMorell, María
dc.contributor.authorAlarcón Riquelme, Marta Eugenia 
dc.date.accessioned2021-06-07T08:20:08Z
dc.date.available2021-06-07T08:20:08Z
dc.date.issued2021-05-12
dc.identifier.citationGómez Hernández, G.; Morell, M.; Alarcón-Riquelme, M.E. The Role of BANK1 in B Cell Signaling and Disease. Cells 2021, 10, 1184. [https://doi.org/10.3390/cells10051184]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/69010
dc.descriptionThe preparation of this review was funded by the Ministerio de Economia y Competitividad (now Ministerio de Ciencia e Innovacion) of the Government of Spain with number SAF2016-78631-P. G.G.H. is supported through this grant.es_ES
dc.descriptionFigure 1 was created with https://biorender.com/ on 29 April 2021.es_ES
dc.description.abstractThe B cell scaffold protein with ankyrin repeats (BANK1) is expressed primarily in B cells and with multiple but discrete roles in B cell signaling, including B cell receptor signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. The gene for BANK1, located in chromosome 4, has been found to contain genetic variants that are associated with several autoimmune diseases and also other complex phenotypes, in particular, with systemic lupus erythematosus. Common genetic variants are associated with changes in BANK1 expression in B cells, while rare variants modify their capacity to bind efferent effectors during signaling. A BANK1-deficient model has shown the importance of BANK1 during TLR7 and TLR9 signaling and has confirmed its role in the disease. Still, much needs to be done to fully understand the function of BANK1, but the main conclusion is that it may be the link between different signaling functions within the B cells and they may act to synergize the various pathways within a cell. With this review, we hope to enhance the interest in this molecule.es_ES
dc.description.sponsorshipSpanish Government SAF2016-78631-Pes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectB cells es_ES
dc.subjectB cell receptores_ES
dc.subjectCD40es_ES
dc.subjectAutoimmunityes_ES
dc.subjectGenetic associationes_ES
dc.subjectB cell scaffold with ankyrin repeatses_ES
dc.subjectTLR7es_ES
dc.subjectBLKes_ES
dc.subjectLYNes_ES
dc.subjectTRAF6es_ES
dc.titleThe Role of BANK1 in B Cell Signaling and Diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/cells10051184
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
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