Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
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AuthorMartín Pérez, Antonio José; Fernández González, María; Postigo Martín, Elisa Paula; Sampedro Pilegaard, Marc; Fernández Lao, Carolina; Castro Martín, Eduardo; Martín Martín, Lydia María; Lozano Lozano, Mario
Systematic reviewNeoplasm metastasisBone and bonesSpinePainProtocol
Martin-Perez, A.J.; Fernández-González, M.; Postigo-Martin, P.; Sampedro Pilegaard, M.; Fernández-Lao, C.; Castro-Martín, E.; Martín-Martín, L.; Lozano-Lozano, M. Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2021, 18, 3991. [https://doi.org/10.3390/ijerph18083991]
SponsorshipUniversity of Granada, Plan Propio de Investigacion 2016, Excellence action: Units of Excellence; University of Granada, Plan Propio de Investigacion 2016, Excellence action: Unit of Excellence on Exercise and Health (UCEES)
There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis.
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