Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State
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AuthorSánchez González, Cristina; Rivas García, Lorenzo; Rodríguez Nogales, Alba; Algieri, Francesca; Gálvez Peralta, Julio Juan; Aranda Ramírez, Pilar; Montes Bayón, María; Llopis González, Juan
Sánchez-González, C.; Rivas-García, L.; Rodríguez-Nogales, A.; Algieri, F.; Gálvez, J.; Aranda, P.; Montes-Bayón, M.; Llopis, J. Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State. Nutrients 2021, 13, 1256. [https://doi.org/10.3390/nu13041256]
SponsorshipConsejeria de Innovacion, Ciencia y Empresa, Andalusian Regional Government P06-CTS-01435; Spanish Ministry of Economy and Competitivity SAF2011-29648; Instituto de Salud Carlos III European Commission
Diabetes is a disease with an inflammatory component that courses with an anemic state. Vanadium (V) is an antidiabetic agent that acts by stimulating insulin signaling. Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits. We aim to investigate the effect of V on hepcidin mRNA expression and its consequences on the hematological parameters in streptozotocin-induced diabetic Wistar rats. Control healthy rats, diabetic rats, and diabetic rats treated with 1 mgV/day were examined for five weeks. The mineral levels were measured in diet and serum samples. Hepcidin expression was quantified in liver samples. Inflammatory and hematological parameters were determined in serum or whole blood samples. The inflammatory status was higher in diabetic than in control rats, whereas the hematological parameters were lower in the diabetic rats than in the control rats. Hepcidin mRNA expression was significantly lower in the V-treated diabetic rats than in control and untreated diabetic rats. The inflammatory status remained at a similar level as the untreated diabetic group. However, the hematological profile improved after the V-treatment, reaching similar levels to those found in the control group. Serum iron level was higher in V-treated than in untreated diabetic rats. We conclude that V reduces gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.