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dc.contributor.authorHidalgo Gutiérrez, Agustín 
dc.contributor.authorGonzález García, Pilar 
dc.contributor.authorDíaz Casado, María Elena 
dc.contributor.authorBarriocanal Casado, Eliana 
dc.contributor.authorLópez Herrador, Sergio 
dc.contributor.authorQuinzii, Catarina M.
dc.contributor.authorLópez García, Luis Carlos 
dc.date.accessioned2021-05-21T11:05:25Z
dc.date.available2021-05-21T11:05:25Z
dc.date.issued2021-03-26
dc.identifier.citationHidalgo-Gutiérrez, A.; González-García, P.; Díaz-Casado, M.E.; Barriocanal-Casado, E.; López-Herrador, S.; Quinzii, C.M.; López, L.C. Metabolic Targets of Coenzyme Q10 in Mitochondria. Antioxidants 2021, 10, 520. [https://doi.org/10.3390/antiox10040520]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/68618
dc.descriptionThis work was supported by grants from Ministerio de Ciencia e Innovacion, Spain, and the ERDF (RTI2018-093503-B-100), the Muscular Dystrophy Association (MDA-602322). C.M.Q. is supported by the Department of Defense (DOD) grant PR190511. A.H.-G. and P.G.-G. are `FPU fellows' from the Ministerio de Universidades, Spain. S.L.-H. is supported by the "becas de colaboracion" from the Ministerio de Universidades, Spain. E.B.-C. is supported by the Consejeria de Salud, Junta de Andalucia, Spain.es_ES
dc.descriptionWe thank Stacy Kelly Aguirre for the English editing. Figures created with BioRender.com.es_ES
dc.description.abstractCoenzyme Q10 (CoQ(10)) is classically viewed as an important endogenous antioxidant and key component of the mitochondrial respiratory chain. For this second function, CoQ molecules seem to be dynamically segmented in a pool attached and engulfed by the super-complexes I + III, and a free pool available for complex II or any other mitochondrial enzyme that uses CoQ as a cofactor. This CoQ-free pool is, therefore, used by enzymes that link the mitochondrial respiratory chain to other pathways, such as the pyrimidine de novo biosynthesis, fatty acid beta-oxidation and amino acid catabolism, glycine metabolism, proline, glyoxylate and arginine metabolism, and sulfide oxidation metabolism. Some of these mitochondrial pathways are also connected to metabolic pathways in other compartments of the cell and, consequently, CoQ could indirectly modulate metabolic pathways located outside the mitochondria. Thus, we review the most relevant findings in all these metabolic functions of CoQ and their relations with the pathomechanisms of some metabolic diseases, highlighting some future perspectives and potential therapeutic implications.es_ES
dc.description.sponsorshipSpanish Governmentes_ES
dc.description.sponsorshipEuropean Commission RTI2018-093503-B-100es_ES
dc.description.sponsorshipMuscular Dystrophy Association MDA-602322es_ES
dc.description.sponsorshipUnited States Department of Defense PR190511es_ES
dc.description.sponsorshipMinisterio de Universidades, Spaines_ES
dc.description.sponsorshipJunta de Andaluciaes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectCoenzyme Q10es_ES
dc.subjectUbiquinone-10es_ES
dc.subjectUbiquinol-10es_ES
dc.subjectMitochondriaes_ES
dc.subjectOxPhoses_ES
dc.subjectSuper-complexeses_ES
dc.subjectSulfide metabolismes_ES
dc.subjectOne-carbon metabolismes_ES
dc.subjectProline metabolismes_ES
dc.titleMetabolic Targets of Coenzyme Q10 in Mitochondriaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/antiox10040520
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España