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dc.contributor.authorAcuña Morales, Inmaculada 
dc.contributor.authorTorres Espinola, Francisco Jose
dc.contributor.authorLópez Moreno, Ana 
dc.contributor.authorAguilera Gómez, Margarita 
dc.contributor.authorSuárez García, Antonio Francisco 
dc.contributor.authorCampoy Folgoso, Cristina
dc.identifier.citationAcuña, I.; Cerdó, T.; Ruiz, A.; Torres-Espínola, F.J.; López-Moreno, A.; Aguilera, M.; Suárez, A.; Campoy, C. Infant Gut Microbiota Associated with Fine Motor Skills. Nutrients 2021, 13, 1673.
dc.description.abstractBACKGROUND: During early life, dynamic gut colonization and brain development co-occur with potential cross-talk mechanisms affecting behaviour. METHODS: We used 16S rRNA gene sequencing to examine the associations between gut microbiota and neurodevelopmental outcomes assessed by the Bayley Scales of Infant Development III in 71 full-term healthy infants at 18 months of age. We hypothesized that children would differ in gut microbial diversity, enterotypes obtained by Dirichlet multinomial mixture analysis and specific taxa based on their behavioural characteristics. RESULTS: In children dichotomized by behavioural trait performance in above- and below-median groups, weighted Unifrac b-diversity exhibited significant differences in fine motor (FM) activity. Dirichlet multinomial mixture modelling identified two enterotypes strongly associated with FM outcomes. When controlling for maternal pre-gestational BMI and breastfeeding for up to 3 months, the examination of signature taxa in FM groups showed that Turicibacter and Parabacteroides were highly abundant in the below-median FM group, while Collinsella, Coprococcus, Enterococcus, Fusobacterium, Holdemanella, Propionibacterium, Roseburia, Veillonella, an unassigned genus within Veillonellaceae and, interestingly, probiotic Bifidobacterium and Lactobacillus were more abundant in the above-median FM group. CONCLUSIONS: Our results suggest an association between enterotypes and specific genera with FM activity and may represent an opportunity for probiotic interventions relevant to treatment for motor disorders.es_ES
dc.description.sponsorshipSpanish Ministry of Innovation and Sciencees_ES
dc.description.sponsorshipJunta de Andalucía: Excellence Projects (P06-CTS-02341)es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-02) and partially funded by the European Commission MyNewGut FP7 EU Project (Grant agreement n◦ 613979)es_ES
dc.description.sponsorshipMyNewGut FP7 EU Project (Grant agreement n◦ 613979)es_ES
dc.description.sponsorshipDynaHEALTH EU Project HORIZON 2020 (Grant agreement n◦ : 633595-2)es_ES
dc.description.sponsorshipMarie Curie post-doctoral fellowship (FP7, no. 329812, NutriOmics)es_ES
dc.description.sponsorshipSpanish Ministry of Education, Culture and Sports (FPU16/04587)es_ES
dc.rightsAtribución 3.0 España*
dc.subjectGut–brain axises_ES
dc.subjectFine motricityes_ES
dc.titleInfant Gut Microbiota Associated with Fine Motor Skillses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España