Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study
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Chronic lymphocytic leukemiaCancerNOVA classificationUltra-processed foodsCasecontrol study
Solans, M.; Fernández-Barrés, S.; Romaguera, D.; Benavente, Y.; Marcos-Gragera, R.; Gracia-Lavedan, E.; Costas, L.; Robles, C.; Gonzalez-Barca, E.; de la Banda, E.; et al. Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study. Int. J. Environ. Res. Public Health 2021, 18, 5457. https://doi.org/10.3390/ijerph18105457
SponsorshipSpanish Ministry of Economy and Competitiveness Carlos III Institute of Health; FEDER funds/European Regional Development Fund (ERDF) (grants PI17/01280, PI11/01810, PI14/01219, PI11/02213, PI09/1662, PI15/00966, PI18/00909, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, Rio Hortega CM13/00232, Juan de la Cierva de Incorporacion IJCI-2016-29502 and SV-09-CLINIC-1); Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP, Spain); Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme/Generalitat de Catalunya for institutional support(2017SGR1085); European Regional Development FundERDF/FEDER; Spanish Ministerio de Economía y Competitividad (MINECO); ISCIII-Sub-Directorate General for Evaluation and the European Regional Development Fund (FEDER-”Una manera de Hacer Europa”) and CIBERONC.; Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S); Generalitat de Catalunya - CERCA Program
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within <1 year (incident), each 10% increment in the consumption of UPF was associated with a 22% higher odds ratio of CLL (95% CI: 1.02, 1.47) suggesting that the overall results might be affected by the inclusion of prevalent cases, who might have changed their dietary habits after cancer diagnosis. Given the low number of cases in the subgroup analyses and multiple tests performed, chance findings cannot totally be ruled out. Nonetheless, positive associations found in CLL incident cases merit further research, ideally in well-powered studies with a prospective design.