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dc.contributor.authorCrespo Ferrer, Pascual Vicente 
dc.contributor.authorCampos Sánchez, Fernando 
dc.contributor.authorLeal, Manuel
dc.contributor.authorMaraver, Francisco
dc.date.accessioned2021-05-10T07:27:54Z
dc.date.available2021-05-10T07:27:54Z
dc.date.issued2021-03-22
dc.identifier.citationCrespo, P.-V.; Campos, F.; Leal, M.; Maraver, F. Effects of Sodium Chloride-Rich MineralWater on Intestinal Epithelium. Experimental Study. Int. J. Environ. Res. Public Health 2021, 18, 3261. [https://doi.org/10.3390/ijerph18063261]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/68421
dc.descriptionThis study was financed by the research groups CTS-115 (Universidad de Granada, Tissue Engineering) and UCM-911757 (Universidad Complutense de Madrid, Medical Hydrology).es_ES
dc.description.abstractSince knowledge concerning the cellular and tissue substrate that explains the therapeutic action of mineral waters is generally very scarce, we address the different effects that Lanjaron-Capuchina mineral water exerts on the intestinal epithelium in an experimental model as a prototype of the sodium chloride-rich mineral waters used in digestive disorders. In the experimental protocol, two groups of five adult Wistar rats received unrestricted mineral water in their diet or mineral water directly into the gastrointestinal tract through a catheter. A third control group was given a standard diet and water ad libitum. Intestinal samples for scanning electron microscopy were analyzed according to standardized methods. The observations carried out by microscope after the administration of the sodium chloride-rich mineral water clearly indicate that the hypertonic action of this mineral water affects the structure of the intestinal epithelium. It modifies the microvilli absorption in terms of the groups of enterocytes and the secretion of goblet cells, but it particularly affects the epithelial renewal process, accelerating and stimulating cell extrusion. The type of extrusion mechanism observed by microscope allows us to affirm that, although this increased after direct administration, it does not generate an epithelial disruption as it occurs in other circumstances with other extrusion modalities.es_ES
dc.description.sponsorshipUniversidad de Granada, Tissue Engineering CTS-115es_ES
dc.description.sponsorshipUniversidad Complutense de Madrid, Medical Hydrology UCM-911757es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectBalneologyes_ES
dc.subjectSodium chloride mineral wateres_ES
dc.subjectHydropinic therapyes_ES
dc.subjectDrinking curees_ES
dc.subjectIntestinal epitheliumes_ES
dc.subjectOsmotic effectes_ES
dc.subjectScanning electron microscopy es_ES
dc.subjectRats es_ES
dc.subjectAnimal studyes_ES
dc.titleEffects of Sodium Chloride-Rich Mineral Water on Intestinal Epithelium. Experimental Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/ijerph18063261
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España