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dc.contributor.authorPlaza Díaz, Julio 
dc.contributor.authorGil Hernández, Ángel 
dc.date.accessioned2021-05-07T11:50:05Z
dc.date.available2021-05-07T11:50:05Z
dc.date.issued2021
dc.identifier.citationPlaza-Diaz, J.; Bernal, M.J.; Schutte, S.; Chenoll, E.; Genovés, S.; Codoñer, F.M.; Gil, A.; Sanchez-Siles, L.M. Effects of Whole-Grain and Sugar Content in Infant Cereals on Gut Microbiota at Weaning: A Randomized Trial. Nutrients 2021, 13, 1496. https://doi.org/10.3390/ nu13051496es_ES
dc.identifier.urihttp://hdl.handle.net/10481/68397
dc.description.abstractThe introduction of complementary foods during infancy marks an important step in the development of the infant gut microbiome. Infant cereals are popular weaning foods but consistent evidence on their effect on the intestinal microbiota, especially when differing in nutritional quality, is lacking. Fecal samples from 4–7-month-old Spanish infants who consumed infant cereals differing in whole grain and sugar content as first weaning foods were analyzed on changes in microbial composition by massively parallel sequencing of the 16S ribosomal RNA gene at baseline and after 7 weeks of intervention. Samples were obtained from a previous trial conducted in Spain demonstrating whole-grain cereal acceptability. In total, samples of 18 infants consuming 0% whole grain cereals with 24 g sugar (0-WG) and 25 infants consuming 50% whole grain cereals with 12 g sugar (50-WG) were analyzed. Microbial composition changed significantly over time (p = 0.001), per intervention group (p = 0.029) and per infant (p = 0.001). Abundance of genus Veillonella increased in both groups while Enterococcus decreased. Within the 0-WG group, phylum Actinobacteria decreased along with genus Bifidobacterium. In the 50-WG, we observed an increase in Lachnoclostridium and Bacteroides. In addition, 50-WG decreased Proteobacteria and Escherichia to levels lower than 0-WG. Although weaning itself appeared to be responsible for most changes, the increased presence of anaerobic fermenters together with inhibition of pathogenic Escherichia may indicate a supporting effect of infant cereals with 50% whole grains and a reduced sugar content over infant cereals manufactured with refined hydrolyzed flours on the infant microbiota. In fact, using a novel methodology for the identification of microbial signatures, we found two groups of microbial taxa predictive of infants consuming enriched whole-grain infant cereals with a high predictive value of about 93%.es_ES
dc.description.sponsorshipEuropean funding from ICEX and FEDER—Program R + D Invest 539 in Spain 2015es_ES
dc.description.sponsorshipEuropean Regional Development Fund: 201503473es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectInfant cerealses_ES
dc.subjectInfant foodes_ES
dc.subjectWhole grainses_ES
dc.subjectComplementary feedinges_ES
dc.subjectIntestinal microbiotaes_ES
dc.titleEffects of Whole-Grain and Sugar Content in Infant Cereals on Gut Microbiota at Weaning: A Randomized Triales_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/ nu13051496


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España