Bisphenol A as a Risk Factor in Prostate Cancer
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Archivos de Medicina Universitaria
Gascón-Mora A, Ruiz-Trescastro C. Bisphenol A as a Risk Factor in Prostate Cancer. AMU. 2020; 2(1):70-83
Prostate cancer is a public health problem and the second leading cause of cancer-related death in men (1- 3). Its etiology is not clear, although it is related to age, ethnicity and genetic factors (4). Its incidence has been increasing, not only because of early diagnosis but also because there seem to be other factors related to its pathogenesis, such as carcinogenic agents of the environment (5). Some of the food packaging found nowadays in supermarkets are made of plastic. There is controversy about the use of this material due to the possible adverse effects on health caused by the compounds forming them. In the first place, among the problems that plastic present for human health, we identified the migration of certain compounds forming them. Migration consists in the transfer of certain substances from the packaging into the food. Bisphenol A (BPA) can be found among these compounds. BPA is a monomer used in the production of plastic from carbonate sources that has been categorized as an endocrine-disrupting compound (EDC). Moreover, it is also used in the inner lining of other types of containers, such as cans. Some data associate the possible adverse effects derived from its exposure with the emergence of different diseases (e.g. diabetes, polycystic ovarian syndrome, metabolic syndrome, and obesity, among others). However, the International Agency for Research on Cancer (IARC) does not consider this element as a risk factor in the development of any type of cancer. Therefore, future studies are required to accurately assess the negative impact of BPA on the development of cancer in humans. This review attempts to examine the relation between this compound and the development of prostate cancer.