Obesity and Prostate Cancer – A Good or Bad Prognostic Factor? A Literature Review (2015-February 2020)
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Archivos de Medicina Universitaria
BMIObesityBody mass indexProstate cancerSpecific mortalityPrognosis
Olea-Rodríguez P, Pérez-Núñez J.J. Obesity and Prostate Cancer – A Good or Bad Prognostic Factor? A Literature Review (2015-February 2020). AMU. 2020; 2(1):18-33
Introduction: Prostate cancer is one of the most prevalent cancers among men. An increase of 35,126 new cases is expected by 2020 in Spain alone. The aim of this review is to study the relationship between obesity and the prognosis of prostate cancer, which is playing an increasingly important role in our health system. Method: A systematic search in several databases (MEDLINE, Web of Science core collection and SCOPUS) was conducted. This search included only observational studies (cohort and case-control studies) from 2015 to February 2020 on prostate cancer-specific mortality and one obesity marker (body mass index, BMI). The data extracted are the Hazard Ratio. Results: 8 studies (7 prospective cohorts and 1 retrospective cohort) were obtained from the search carried out for this review and their Hazard Ratio was analyzed. A positive association was obtained in 5 studies for a BMI>27.5 kg/m² and BMI<22.5 kg/m². Paradoxically, one associated a protective association for a BMI<25 kg/m². Conclusion: The literature reviewed indicates that obesity appears to be a bad prognostic factor in prostate cancer. However, there is not enough scientific evidence to validate this statement as no studies with conclusive results were found. Therefore, more studies with other, more specific obesity factors are needed in order to conduct a more comprehensive analysis to confirm this association.