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dc.contributor.authorZwir Nawrocki, Jorge Sergio Igor 
dc.contributor.authorVal Muñoz, María Coral Del 
dc.contributor.authorRomero Zaliz, Rocio Celeste 
dc.contributor.authorArnedo, Javier
dc.contributor.authorAcosta Mesas, Alberto 
dc.date.accessioned2021-04-21T11:36:38Z
dc.date.available2021-04-21T11:36:38Z
dc.date.issued2021
dc.identifier.citationZwir, C. Del-Val, M. Hintsanen, K.M. Cloninger, R. Romero-Zaliz, A. Mesa, J. Arnedo, R. Salas, G.F. Poblete, E. Raitoharju, O. Raitakari, L. Keltikangas-Järvinen, G. de Erausquin, I. Tattersall, T. Lehtimäki, C. R. Cloninger. Evolution of Genetic Networks for Human Creativity. Mol Psychiatry 2021, https://doi.org/10.1038/s41380-021-01097-yes_ES
dc.identifier.urihttp://hdl.handle.net/10481/68042
dc.description.abstractThe genetic basis for the emergence of creativity in modern humans remains a mystery despite sequencing the genomes of chimpanzees and Neanderthals, our closest hominid relatives. Data-driven methods allowed us to uncover networks of genes distinguishing the three major systems of modern human personality and adaptability: emotional reactivity, self-control, and self-awareness. Now we have identified which of these genes are present in chimpanzees and Neanderthals. We replicated our findings in separate analyses of three high-coverage genomes of Neanderthals. We found that Neanderthals had nearly the same genes for emotional reactivity as chimpanzees, and they were intermediate between modern humans and chimpanzees in their numbers of genes for both self-control and self-awareness. 95% of the 267 genes we found only in modern humans were not protein-coding, including many long-non-coding RNAs in the self-awareness network. These genes may have arisen by positive selection for the characteristics of human well-being and behavioral modernity, including creativity, prosocial behavior, and healthy longevity. The genes that cluster in association with those found only in modern humans are over-expressed in brain regions involved in human self-awareness and creativity, including late-myelinating and phylogenetically recent regions of neocortex for autobiographical memory in frontal, parietal, and temporal regions, as well as related components of cortico-thalamo-ponto-cerebellar-cortical and cortico-striato-cortical loops. We conclude that modern humans have more than 200 unique non-protein-coding genes regulating co-expression of many more proteincoding genes in coordinated networks that underlie their capacities for self-awareness, creativity, prosocial behavior, and healthy longevity, which are not found in chimpanzees or Neanderthals.es_ES
dc.language.isoenges_ES
dc.publisherSPRINGERes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectGenetics es_ES
dc.subjectCreativityes_ES
dc.subjectHuman evolution es_ES
dc.titleEvolution of genetic networks for human creativityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41380- 021-01097-y


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Except where otherwise noted, this item's license is described as Atribución 3.0 España