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dc.contributor.authorRobles Vera, Iñaki 
dc.contributor.authorde la Visitación, Néstor
dc.contributor.authorSánchez, Manuel
dc.contributor.authorGómez Guzmán, Manuel 
dc.contributor.authorJiménez Moleón, Rosario 
dc.contributor.authorRomero, Miguel
dc.contributor.authorDuarte Pérez, Juan Manuel 
dc.date.accessioned2021-04-21T10:08:07Z
dc.date.available2021-04-21T10:08:07Z
dc.date.issued2020-12-31
dc.identifier.citationIñaki Robles-Vera, Néstor de la Visitación, Marta Toral, Manuel Sánchez, Manuel Gómez-Guzmán, Rosario Jiménez, Miguel Romero, Juan Duarte, Mycophenolate mediated remodeling of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rats, Biomedicine & Pharmacotherapy, Volume 135, 2021, 111189, ISSN 0753-3322, [https://doi.org/10.1016/j.biopha.2020.111189]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/68037
dc.descriptionThis work was supported by Grants from Comisi´on Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad (SAF2017-84894-R), Junta de Andalucía (CTS-164) with funds from the European Union, Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (CIBER-CV), Spain. M.T. is a postdoctoral fellow of Instituto de Salud Carlos III (Sara Borrell Program). I.R.-V. is a predoctoral fellow of MINECO. The cost of this publication was paid in part with funds from the European Union (Fondo Europeo de Desarrollo Regional, FEDER, “FEDER una manera de hacer Europa”).es_ES
dc.description.abstractMicrobiota has a role in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzes whether MMF improves dysbiosis in a genetic model of hypertension. Twenty weeks old male spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were randomly divided into three groups: untreated WKY, untreated SHR, and SHR treated with MMF for 5 weeks. MMF treatment restored gut bacteria from the phyla Firmicutes and Bacteroidetes, and acetate- and lactate-producing bacteria to levels similar to those found in WKY, increasing butyrate-producing bacteria. MMF increased the percentage of anaerobic bacteria in the gut. The improvement of gut dysbiosis was associated with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited neuroinflammation in the paraventricular nuclei in the hypothalamus. MMF increased the lower regulatory T cells proportion in mesenteric lymph nodes and Th17 and Th1 infiltration in aorta, improved aortic endothelial function and reduced systolic BP. This study demonstrates for the first time that MMF reduces gut dysbiosis in SHR. This effect could be related to its capability to improve gut integrity due to reduced sympathetic drive in the gut associated to the reduced brain neuroinflammation.es_ES
dc.description.sponsorshipComision Interministerial de Ciencia y Tecnologia, Ministerio de Economia y competitividad SAF201784894Res_ES
dc.description.sponsorshipJunta de Andalucia CTS-164es_ES
dc.description.sponsorshipEuropean Commissiones_ES
dc.description.sponsorshipSpanish Governmentes_ES
dc.description.sponsorshipInstituto de Salud Carlos III (CIBERCV) , Spaines_ES
dc.description.sponsorshipEuropean Union (Fondo Europeo de Desarrollo Regional, FEDER, "FEDER una manera de hacer Europa")es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectMycophenolatees_ES
dc.subjectGut dysbiosises_ES
dc.subjectHypertension es_ES
dc.subjectOxidative stress es_ES
dc.subjectInflammation es_ES
dc.subjectSHRes_ES
dc.titleMycophenolate mediated remodeling of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive ratses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1016/j.biopha.2020.111189
dc.type.hasVersionVoRes_ES


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