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dc.contributor.authorSierra Sánchez, Álvaro
dc.contributor.authorMontero Vilchez, Trinidad
dc.contributor.authorQuiñones Vico, María Isabel 
dc.contributor.authorSánchez Diaz, Manuel
dc.contributor.authorArias Santiago, Salvador Antonio
dc.identifier.citationSierra-Sánchez Á, Montero-Vilchez T, Quiñones-Vico MI, Sanchez-Diaz M and Arias-Santiago S (2021) Current Advanced Therapies Based on Human Mesenchymal Stem Cells for Skin Diseases. Front. Cell Dev. Biol. 9:643125. [doi: 10.3389/fcell.2021.643125]es_ES
dc.description.abstractSkin disease may be related with immunological disorders, external aggressions, or genetic conditions. Injuries or cutaneous diseases such as wounds, burns, psoriasis, and scleroderma among others are common pathologies in dermatology, and in some cases, conventional treatments are ineffective. In recent years, advanced therapies using human mesenchymal stem cells (hMSCs) from different sources has emerged as a promising strategy for the treatment of many pathologies. Due to their properties; regenerative, immunomodulatory and differentiation capacities, they could be applied for the treatment of cutaneous diseases. In this review, a total of thirteen types of hMSCs used as advanced therapy have been analyzed, considering the last 5 years (2015–2020). The most investigated types were those isolated from umbilical cord blood (hUCB-MSCs), adipose tissue (hAT-MSCs) and bone marrow (hBM-MSCs). The most studied diseases were wounds and ulcers, burns and psoriasis. At preclinical level, in vivo studies with mice and rats were the main animal models used, and a wide range of types of hMSCs were used. Clinical studies analyzed revealed that cell therapy by intravenous administration was the advanced therapy preferred except in the case of wounds and burns where tissue engineering was also reported. Although in most of the clinical trials reviewed results have not been posted yet, safety was high and only local slight adverse events (mild nausea or abdominal pain) were reported. In terms of effectiveness, it was difficult to compare the results due to the different doses administered and variables measured, but in general, percentage of wound’s size reduction was higher than 80% in wounds, Psoriasis Area and Severity Index and Severity Scoring for Atopic Dermatitis were significantly reduced, for scleroderma, parameters such as Modified Rodnan skin score (MRSC) or European Scleroderma Study Group activity index reported an improvement of the disease and for hypertrophic scars, Vancouver Scar Scale (VSS) score was decreased after applying these therapies. On balance, hMSCs used for the treatment of cutaneous diseases is a promising strategy, however, the different experimental designs and endpoints stablished in each study, makes necessary more research to find the best way to treat each patient and disease.es_ES
dc.description.sponsorshipInstituto de Salud Carlos III (European Regional Development Fund "A way to make Europe") PI13/02576 PI17/02083es_ES
dc.description.sponsorshipAndalusian Regional Government SAS PI-0458-2016 PIGE-0242-2019es_ES
dc.description.sponsorshipInstituto de Salud Carlos III (European Social Fund "Investing in your future") FI18/00269es_ES
dc.publisherFrontiers Media SAes_ES
dc.rightsAtribución 3.0 España*
dc.subjectAdvanced therapieses_ES
dc.subjectCell therapyes_ES
dc.subjectDermatology es_ES
dc.subjectMesenchymal Stem Cellses_ES
dc.subjectSkin diseaseses_ES
dc.subjectSkin injurieses_ES
dc.subjectStem cellses_ES
dc.subjectTissue Engineeringes_ES
dc.titleCurrent Advanced Therapies Based on Human Mesenchymal Stem Cells for Skin Diseaseses_ES

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Atribución 3.0 España
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