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dc.contributor.authorGómez Morales, Jaime
dc.contributor.authorFernández Penas, Raquel
dc.contributor.authorRomero Castillo, Ismael
dc.contributor.authorVerdugo Escamilla, Cristóbal
dc.contributor.authorChoquesillo Lazarte, Duane
dc.contributor.authorFernández Sánchez, Jorge Fernando 
dc.date.accessioned2021-04-09T08:19:05Z
dc.date.available2021-04-09T08:19:05Z
dc.date.issued2021-01-27
dc.identifier.citationGómez-Morales, J.; Fernández-Penas, R.; Romero-Castillo, I.; Verdugo-Escamilla, C.; Choquesillo-Lazarte, D.; D’Urso, A.; Prat, M.; Fernández-Sánchez, J.F. Crystallization, Luminescence and Cytocompatibility of Hexagonal Calcium Doped Terbium Phosphate Hydrate Nanoparticles. Nanomaterials 2021, 11, 322. https://doi.org/ 10.3390/nano11020322es_ES
dc.identifier.urihttp://hdl.handle.net/10481/67870
dc.description.abstractLuminescent lanthanide-containing biocompatible nanosystems represent promising candidates as nanoplatforms for bioimaging applications. Herein, citrate-functionalized calcium-doped terbium phosphate hydrate nanophosphors of the rhabdophane type were prepared at different synthesis times and different Ca2+/Tb3+ ratios by a bioinspired crystallization method consisting of thermal decomplexing of Ca2+/Tb3+/citrate/phosphate/carbonate solutions. Nanoparticles were characterized by XRD, TEM, SEM, HR-TEM, FTIR, Raman, Thermogravimetry, inductively coupled plasma spectroscopy, thermoanalysis, dynamic light scattering, electrophoretic mobility, and fluorescence spectroscopy. They displayed ill-defined isometric morphologies with sizes 50 nm, hydration number n ~ 0.9, tailored Ca2+ content (0.42–8.11 wt%), and long luminescent lifetimes (800–2600 s). Their relative luminescence intensities in solid state are neither affected by Ca2+, citrate content, nor by maturation time for Ca2+ doping concentration in solution below 0.07 M Ca2+. Only at this doping concentration does the maturation time strongly affect this property, decreasing it. In aqueous suspensions, neither pH nor ionic strength nor temperature affect their luminescence properties. All the nanoparticles displayed high cytocompatibility on two human carcinoma cell lines and cell viability correlated positively with the amount of doping Ca2+. Thus, these nanocrystals represent promising new luminescent nanoprobes for potential biomedical applications and, if coupled with targeting and therapeutic moieties, they could be effective tools for theranostics.es_ES
dc.description.sponsorshipSpanish Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades (MICIU)es_ES
dc.description.sponsorshipEuropean Commission PGC2018102047-B-I00es_ES
dc.description.sponsorshipSpanish Ministerio de Economía y Competitividad CTQ2017-88079-Pes_ES
dc.language.isoenges_ES
dc.publisherMdpies_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectTerbiumphosphateses_ES
dc.subjectCalciumdopedes_ES
dc.subjectCitratees_ES
dc.subjectNanoparticleses_ES
dc.subjectLuminescence es_ES
dc.subjectCytocompatibilityes_ES
dc.titleCrystallization, Luminescence and Cytocompatibility of Hexagonal Calcium Doped Terbium Phosphate Hydrate Nanoparticleses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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