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dc.contributor.authorPlaza Díaz, Julio 
dc.contributor.authorÁlvarez Mercado, Ana Isabel
dc.identifier.citationPlaza-Díaz, J.; Solis-Urra, P.; Aragón-Vela, J.; Rodríguez-Rodríguez, F.; Olivares-Arancibia, J.;Álvarez-Mercado, A.I. Insights into the Impact of Microbiota in the Treatment of NAFLD/NASH and Its Potential as a Biomarker for Prognosis and Diagnosis. Biomedicines 2021, 9, 145. []es_ES
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver illness associated with obesity and metabolic disorders, such as hypertension, dyslipidemia, or type 2 diabetes mellitus. A more severe type of NAFLD, non-alcoholic steatohepatitis (NASH), is considered an ongoing global health threat and dramatically increases the risks of cirrhosis, liver failure, and hepatocellular carcinoma. Several reports have demonstrated that liver steatosis is associated with the elevation of certain clinical and biochemical markers but with low predictive potential. In addition, current imaging methods are inaccurate and inadequate for quantification of liver steatosis and do not distinguish clearly between the microvesicular and the macrovesicular types. On the other hand, an unhealthy status usually presents an altered gut microbiota, associated with the loss of its functions. Indeed, NAFLD pathophysiology has been linked to lower microbial diversity and a weakened intestinal barrier, exposing the host to bacterial components and stimulating pathways of immune defense and inflammation via toll-like receptor signaling. Moreover, this activation of inflammation in hepatocytes induces progression from simple steatosis to NASH. In the present review, we aim to: (a) summarize studies on both human and animals addressed to determine the impact of alterations in gut microbiota in NASH; (b) evaluate the potential role of such alterations as biomarkers for prognosis and diagnosis of this disorder; and (c) discuss the involvement of microbiota in the current treatment for NAFLD/NASH (i.e., bariatric surgery, physical exercise and lifestyle, diet, probiotics and prebiotics, and fecal microbiota transplantation).es_ES
dc.description.sponsorshipNational Agency for Research and Development (ANID) BECAS Chile 72180543es_ES
dc.description.sponsorship"Fundación Ramon Areces", Madrid, Spaines_ES
dc.description.sponsorship'Fundación Alfonso Martin Escudero' (Spain)es_ES
dc.rightsAtribución 3.0 España*
dc.subjectNon-alcoholic steatohepatitises_ES
dc.subjectIntestinal permeabilityes_ES
dc.subjectPhysical exercisees_ES
dc.subjectFecal microbiota transplantationes_ES
dc.titleInsights into the Impact of Microbiota in the Treatment of NAFLD/NASH and Its Potential as a Biomarker for Prognosis and Diagnosises_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España