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dc.contributor.authorLlorente Cantarero, Francisco Jesús
dc.contributor.authorAnguita Ruiz, Augusto
dc.contributor.authorMesa García, María Dolores 
dc.contributor.authorGil Hernández, Ángel 
dc.contributor.authorAguilera García, Concepción María
dc.identifier.citationLlorente-Cantarero, F.J.; Aguilar-Gómez, F.J.; Leis, R.; Bueno, G.; Rupérez, A.I.; Anguita-Ruiz, A.; Vázquez-Cobela, R.; Mesa, M.D.; Moreno, L.A.; Gil, Á.; et al. Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study. Antioxidants 2021, 10, 320. []es_ES
dc.description.abstractThe World Health Organization has recommended performing at least 60 min a day of moderate-to-vigorous physical activity (MVPA) and reducing sedentarism in children and adolescents to offer significant health benefits and mitigate health risks. Physical fitness and sports practice seem to improve oxidative stress (OS) status during childhood. However, to our knowledge, there are no data regarding the influence of objectively-measured physical activity (PA) and sedentarism on OS status in children and adolescents. The present study aimed to evaluate the influence of moderate and vigorous PA and sedentarism on OS and plasma total antioxidant capacity (TAC) in a selected Spanish population of 216 children and adolescents from the GENOBOX study. PA (light, moderate, and vigorous) and sedentarism (i.e., sedentary time (ST)) were measured by accelerometry. A Physical Activity-Sedentarism Score (PASS) was developed integrating moderate and vigorous PA and ST levels. Urinary 8-hydroxy-20-deoxyguanosine (8-OHdG) and isoprostane F2 (F2-IsoPs), as markers of OS, were determined by ELISA; and TAC was estimated by colorimetry using an antioxidant kit. A higher PASS was associated with lower plasma TAC and urinary 8-OHdG and F2-IsoPs, showing a better redox profile. Reduced OS markers (8-OHdG and F2-IsoPs) in children with higher PASS may diminish the need of maintaining high concentrations of antioxidants in plasma during rest to achieve redox homeostasis.es_ES
dc.description.sponsorshipPlan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) PI11/02042 PI11/02059 PI11/01425 PI16/00871 PI16/01301 PI16/01205es_ES
dc.description.sponsorshipRETIC (Redes temáticas de investigación cooperativa) Red SAMID RD12/0026/0015es_ES
dc.description.sponsorshipInstituto de Salud Carlos III European Commission IFI17/00048es_ES
dc.description.sponsorshipResearch Plan of the Vice-Rectorate of Research and Transfer of the University of Granada, Spaines_ES
dc.rightsAtribución 3.0 España*
dc.subjectPhysical activityes_ES
dc.subjectOxidative stress es_ES
dc.subjectPlasma total antioxidant capacityes_ES
dc.subjectisoprostane F2es_ES
dc.titleRelationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Studyes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España