Mostrar el registro sencillo del ítem

dc.contributor.authorPérez Torres, Juana 
dc.contributor.authorMuñoz Dorado, José 
dc.contributor.authorMoraleda Muñoz, Aurelio 
dc.date.accessioned2021-03-17T13:07:53Z
dc.date.available2021-03-17T13:07:53Z
dc.date.issued2018-07-18
dc.identifier.citationPérez J, Muñoz-Dorado J, Moraleda-Muñoz A. The complex global response to copper in the multicellular bacterium Myxococcus xanthus. Metallomics. 2018 Jul 18;10(7):876-886. doi: 10.1039/c8mt00121a. PMID: 29961779.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/67294
dc.description.abstractBacteria must adapt to fluctuations in their environment to survive. One of the most interesting challenges they must cope with is changes in metal concentrations. Many metals are essential for viability, since they act as cofactors of indispensable enzymes. But on the other hand, they are potentially toxic because they generate reactive oxygen species or displace other metals from proteins, turning them inactive. This dual effect of metals forces cells to maintain homeostasis by using a variety of systems to import and export them. These systems are usually inducible, and their expression is regulated by metal sensors and signal-transduction mechanisms, one of which is mediated by extracytoplasmic function (ECF) sigma factors. In this review we have focused on the metal-responsive ECF sigma factors, several of which are activated by iron depletion (FecI, FpvI, and PvdS), while others are activated by excess of metals such as nickel and cobalt (CnrH), copper (CarQ and CorE), or cadmium and zinc (CorE2). We focus particularly on their physiological roles, mechanisms of action and signal-transduction pathways.es_ES
dc.description.sponsorshipThis work has been supported by the Spanish Government, grants CSD2009-00006 and BFU2012-33248 to José Muñoz-Dorado, and BFU2016-75425-P to Aurelio Moraleda-Muñoz (70% funded by FEDER).es_ES
dc.language.isoenges_ES
dc.publisherThe Royal Society of Chemistryes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectGene expressiones_ES
dc.subjectSignal transductiones_ES
dc.subjectMetal homeostasises_ES
dc.subjectECF sigma factorses_ES
dc.titleThe complex global response to copper in the multicellular bacterium Myxococcus xanthuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1039/c8mt00121a
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES


Ficheros en el ítem

[PDF]

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución-NoComercial-SinDerivadas 3.0 España
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución-NoComercial-SinDerivadas 3.0 España