Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer
Metadatos
Afficher la notice complèteEditorial
Nature Research
Date
2021-01-21Referencia bibliográfica
López, D. M. L., Hinojo, C. A. B., Lara, M. C., Sánchez-Prieto, M., Sánchez-Borrego, R., de Guevara, N. M. L., & Mesa, E. G. (2021). Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer. Scientific Reports, 11(1), 1-12. [https://doi.org/10.1038/s41598-021-81436-9]
Résumé
The objective of this study was to investigate whether the BC tumor biology in women with larger
breast volume, in obese women and especially in women with central adiposity at the moment of
diagnosis of BC is more aggressive than in those women without these characteristics. 347 pre- and
postmenopausal women with a recent diagnosis of BC were analyzed. In all patients, anthropometric
measurements at the time of diagnosis was collected. In 103 of them, the breast volume was
measured by the Archimedes method. The Breast volume, BMI, WHR and the menopausal status
were related to different well-known pathological prognostic factors for BC. At the time of diagnosis,
35.4% were obese (BMI > 30 kg/m2), 60.2% had a WHR ≥ 0.85, 68.8% were postmenopausal and 44.7%
had a breast volume considered "large" (> 600 cc). Between patients with a large breast volume, only
a higher prevalence of ER (+) tumors was found (95.3% vs. 77.2%; p = 0.04) compared to those with
small breast volumes. The obese BC patients showed significantly higher rates of large tumors (45.5%
vs. 40.6%; p = 0.04), axillary invasion (53.6% vs. 38.8%; p = 0.04), undifferentiated tumors (38.2%
vs. 23.2%) and unfavorable NPI (p = 0.04) than non-obese women. Those with WHR ≥ 0.85 presented
higher postsurgical tumor stages (61.7% vs. 57.8%; p = 0.03), higher axillary invasion (39.9% vs.
36.0%; p = 0.004), more undifferentiated tumors (30.0% vs. 22.3%; p = 0.009), higher lymphovascular
infiltration (6.5% vs. 1.6%; p = 0.02), and a higher NPI (3.6 ± 1.8 vs. 3.2 ± 1.8; p = 0.04). No statistically
significant differences were found according to menopausal status. We conclude that obesity, but
especially central obesity can be associated with a more aggressive tumour phenotype. No relation
between breast volume and tumoral prognostic factors was found, except for a higher proportion of
ER (+) tumor in women with higher breast volume.