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dc.contributor.authorJayasekara, Harindra
dc.contributor.authorSánchez Pérez, María José
dc.identifier.citationJayasekara, H., MacInnis, R. J., Barroso, L. L., Mayen‐Chacon, A. L., Cross, A. J., Wallner, B., ... & Ferrari, P. (2021). Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies. International journal of cancer. [DOI: 10.1002/ijc.33504]es_ES
dc.description.abstractAlcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.es_ES
dc.description.sponsorshipNational Health and Medical Research Council of Australia 1074383 209057 396414 GNT1163120es_ES
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR) Cancer Council Victoriaes_ES
dc.description.sponsorshipCancer Research UK C570/A16491 C8221/A19170 C864/A14136es_ES
dc.description.sponsorshipCatalan Institute of Oncology - ICO (Spain)es_ES
dc.description.sponsorshipDanish Cancer Societyes_ES
dc.description.sponsorshipDeutsche Krebshilfees_ES
dc.description.sponsorshipDeutsches Krebsforschungszentrum (Germany)es_ES
dc.description.sponsorshipDutch Ministry of Public Health, Welfare and Sportses_ES
dc.description.sponsorshipEuropean Commission European Commission Joint Research Centrees_ES
dc.description.sponsorshipFoundation for Alcohol Research and Education (Australia)es_ES
dc.description.sponsorshipFrench Ministry of Health GR-IARC-2003-09-12-01es_ES
dc.description.sponsorshipHealth Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII)es_ES
dc.description.sponsorshipJunta de Andalucíaes_ES
dc.description.sponsorshipRegional Government of Asturiases_ES
dc.description.sponsorshipBasque Governmentes_ES
dc.description.sponsorshipRegional Government of Murciaes_ES
dc.description.sponsorshipRegional Government of Navarraes_ES
dc.description.sponsorshipHellenic Health Foundation (Greece)es_ES
dc.description.sponsorshipHellenic Ministry of Health and Social Solidarity (Greece)es_ES
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale (Inserm)es_ES
dc.description.sponsorshipConsiglio Nazionale delle Ricerche (CNR)es_ES
dc.description.sponsorshipAssociazione Italiana per la Ricerca sul Cancro (AIRC)es_ES
dc.description.sponsorshipLigue Contre le Cancer (France)es_ES
dc.description.sponsorshipLK Research Fundses_ES
dc.description.sponsorshipDutch Prevention Fundses_ES
dc.description.sponsorshipNetherlands Organization for Scientific Research (NWO)es_ES
dc.description.sponsorshipUK Research & Innovation (UKRI) Medical Research Council UK (MRC) MC-UU_12015/1 MR/M012190/1 MR/N003284/es_ES
dc.description.sponsorshipMutuelle Generale de l'Education Nationalees_ES
dc.description.sponsorshipNational Institute for Public Health and the Environment (RIVM) (the Netherlands)es_ES
dc.description.sponsorshipNetherlands Cancer Registryes_ES
dc.description.sponsorshipStavros Niarchos Foundation (Greece)es_ES
dc.description.sponsorshipStroke Association (UK)es_ES
dc.description.sponsorshipBritish Heart Foundationes_ES
dc.description.sponsorshipDepartment of Health (UK)es_ES
dc.description.sponsorshipFood Standards Agency (UK)es_ES
dc.description.sponsorshipWellcome Trustes_ES
dc.description.sponsorshipSwedish Cancer Societyes_ES
dc.description.sponsorshipSwedish Scientific Council (Sweden)es_ES
dc.description.sponsorshipRegional Government of Skane (Sweden)es_ES
dc.description.sponsorshipFederal Ministry of Education & Research (BMBF)es_ES
dc.description.sponsorshipVicHealth (Australia)es_ES
dc.description.sponsorshipWorld Cancer Research Fund and Statistics Netherlands (the Netherlands)es_ES
dc.description.sponsorshipInstitut Gustave Roussyes_ES
dc.rightsAtribución 3.0 España*
dc.subjectCardia canceres_ES
dc.subjectLifetime alcohol intakees_ES
dc.subjectNoncardia canceres_ES
dc.subjectStomach canceres_ES
dc.titleLifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studieses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España