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dc.contributor.authorToledano Pérez, Manuel 
dc.contributor.authorVallecillo-Rivas, Marta
dc.contributor.authorSánchez Aguilera, Fátima 
dc.contributor.authorOsorio Ruiz, María Estrella 
dc.contributor.authorOsorio Ruiz, Raquel
dc.identifier.citationToledano M, Vallecillo-Rivas M, Aguilera FS, Osorio MT, Osorio E, Osorio R. Polymeric zinc-doped nanoparticles for high performance in restorative Dentistry. Journal of Dentistry. 2021;103580.es_ES
dc.description.abstractObjectives: The aim was to state the different applications and the effectiveness of polymeric zinc-doped nanoparticles to achieve dentin remineralization. Data, Sources and Study selection: Literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken. Conclusions: Polymeric nanospheres (NPs) were efficiently loaded with zinc. NPs sequestered calcium and phosphate in the presence of silicon, and remained effectively embedded at the hybrid layer. NPs incorporation did not alter bond strength and inhibited MMP-mediated dentin collagen degradation. Zn-loaded NPs remineralized the hybrid layer inducing a generalized low-carbonate substitute apatite precipitation, chemically crystalline with some amorphous components, and an increase in mechanical properties was also promoted. Viscoelastic analysis determined that dentin infiltrated with Zn-NPs released the stress by breaking the resin-dentin interface and creating specific mineral formations in response to the energy dissipation. Bacteria were scarcely encountered at the resin-dentin interface. The combined antibacterial and remineralizing effects, when Zn-NPs were applied, reduced biofilm formation. Zn-NPs application at both cervical and radicular dentin attained the lowest microleakage and also promoted durable sealing ability. The new zinc-based salt minerals generated covered the dentin surface totally occluding cracks, porosities and dentinal tubules. Clinical significance: Zinc-doped NPs are proposed for effective dentin remineralization and tubular occlusion. This offers new strategies for regeneration of eroded cervical dentin, effective treatment of dentin hypersensitivity and in endodontically treated teeth previous to the canal filling. Zn-NPs also do reduce biofilm formation due to antibacterial properties.es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectpolymeric nanoparticleses_ES
dc.titlePolymeric zinc-doped nanoparticles for high performance in restorative dentistryes_ES
dc.title.alternativeZn-doped NPs in dentistryes_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España