Mostrar el registro sencillo del ítem

dc.contributor.authorToledano Osorio, Manuel 
dc.contributor.authorOsorio Ruiz, Raquel 
dc.contributor.authorSánchez Aguilera, Fátima 
dc.contributor.authorMedina Castillo, Antonio Luis 
dc.contributor.authorToledano Pérez, Manuel 
dc.contributor.authorOsorio Ruiz, María Estrella 
dc.contributor.authorAcosta, Sergio
dc.contributor.authorChen, Ruoqiong
dc.contributor.authorAparicio, Conrado
dc.date.accessioned2021-03-16T09:16:45Z
dc.date.available2021-03-16T09:16:45Z
dc.date.issued2019-05
dc.identifier.citationToledano-Osorio M, Osorio R, Aguilera FS, Medina-Castillo AL, Toledano M, Osorio E, Acosta S, Chen R, Aparicio C. Polymeric nanoparticles protect the resin-dentin bonded interface from cariogenic biofilm degradation. Acta Biomaterialia 2020;111:316–26.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/67255
dc.description.abstractThe objective was to assess doxycycline (Dox) and zinc (Zn) doped nanoparticles' (NPs) potential to protect the resin-dentin interface from cariogenic biofilm. Three groups ofpolymeric NPs were tested: unloaded, loaded with zinc and with doxycycline. NPs were appliedafter dentin etching. The disks were exposed to a cariogenic biofilm challenge in a Drip-FlowReactor during 72 h and 7 d. Half of the specimens were not subjected to biofilm formation butstored 72 h and 7 d. LIVE/DEAD® viability assay, nano-dynamic mechanicalassessment, Raman spectroscopy and field emission electron microscopy (FESEM) analysiswere performed. The measured bacterial death rates, at 7 d were 46% for the control group, 51%for the undoped-NPs, 32% for Dox-NPs, and 87% for Zn-NPs; being total detected bacteriareduced five times in the Dox-NPs group. Zn-NPs treated samples reached, in general, thehighest complex modulus values at the resin-dentin interface over time. Regarding the mineralcontent, Zn-NPs-treated dentin interfaces showed the highest mineralization degree associatedto the phosphate peak and the relative mineral concentration. FESEM images after Zn-NPsapplication permitted to observe remineralization of the etched and non-resin infiltratedcollagen layer, and bacteria were scarcely encountered. The combined antibacterial andremineralizing effects, when Zn-NPs were applied, reduced biofilm formation. Dox-NPs exertedan antibacterial role but did not remineralize the bonded interface. Undoped-NPs did notimprove the properties of the interfaces. Application of Zn-doped NPs during the bondingprocedure is encouraged.es_ES
dc.language.isoenges_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectdentines_ES
dc.subjectdegradation,es_ES
dc.subjectinterfacees_ES
dc.subjectnanoparticlees_ES
dc.subjectbiofilmes_ES
dc.titlePolymeric nanoparticles protect the resin-dentin bonded interface from cariogenic biofilm degradationes_ES
dc.title.alternativeNanoparticles antidegradation activity at bonded dentines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doihttps://doi.org/10.1016/j.actbio.2020.05.002


Ficheros en el ítem

[PDF]

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución-NoComercial-SinDerivadas 3.0 España
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución-NoComercial-SinDerivadas 3.0 España