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dc.contributor.authorGonzález Cano, Rafael 
dc.contributor.authorMontilla-García, Ángeles
dc.contributor.authorRuiz Cantero, María del Carmen 
dc.contributor.authorBravo Caparrós, Inmaculada
dc.contributor.authorTejada, Miguel Ángel
dc.contributor.authorNieto López, Francisco Rafael 
dc.contributor.authorCobos del Moral, Enrique José
dc.identifier.citationGonzález-Cano R, Montilla-García Á, Ruiz-Cantero MC, Bravo-Caparrós I, Tejada MÁ, Nieto FR, Cobos EJ. The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going? Neurosci Biobehav Rev. 2020 Jun;113:238-261.es_ES
dc.description.abstractPain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli; the results thus may not fully reflect the human pain phenotype. Alterations in physical and emotional functioning, pain-depressed behaviors and facial pain expressions were recently proposed as additional pain outcomes to provide a more accurate measure of clinical pain in rodents, and hence to potentially enhance analgesic drug development. We aimed to review how preclinical pain assessment has evolved since the development of the tail flick test in 1941, with a particular focus on a critical analysis of some nonstandard pain outcomes, and a consideration of how sex differences may affect the performance of these pain surrogates. We tracked original research articles in Medline for the following periods: 1973-1977, 1983-1987, 1993-1997, 2003-2007, and 2014-2018. We identified 606 research articles about alternative surrogate pain measures, 473 of which were published between 2014 and 2018. This indicates that preclinical pain assessment is moving toward the use of these measures, which may soon become standard procedures in preclinical pain laboratories.es_ES
dc.description.sponsorshipFPU grant from the Spanish Ministry of Education, Culture and Sportses_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness (MINECO, grant SAF2016-80540-R)es_ES
dc.description.sponsorshipRamón Areces Foundationes_ES
dc.description.sponsorshipJunta de Andalucía (grant CTS 109)es_ES
dc.description.sponsorshipEsteve Pharmaceuticalses_ES
dc.description.sponsorshipEuropean Regional Development Fund (ERDF)es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectPain es_ES
dc.subjectBehavior es_ES
dc.subjectAnimal modeles_ES
dc.subjectGrip strengthes_ES
dc.subjectPostural changeses_ES
dc.subjectWheel runninges_ES
dc.subjectHome cage activityes_ES
dc.subjectIntracranial self-stimulationes_ES
dc.subjectExploratory activityes_ES
dc.subjectFacial expressionses_ES
dc.titleThe search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?es_ES
dc.relation.projectIDMINECO, grant SAF2016-80540-Res_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España