Reporting of Perinatal Outcomes in Probiotic Randomized Controlled Trials. A Systematic Review and Meta-Analysis
Metadatos
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Pérez Castillo, Íñigo María; Fernández Castillo, Rafael; Lasserrot Cuadrado, Agustín; Gallo Vallejo, José Luis; Rojas Carvajal, Ana María; Aguilar Cordero, María JoséEditorial
Mdpi
Materia
Probiotics Safety Pregnancy Perinatal outcomes Strains Meta-analysis PRISMA
Fecha
2021-01-17Referencia bibliográfica
Pérez-Castillo, Í.M.; Fernández-Castillo, R.; Lasserrot-Cuadrado, A.; Gallo-Vallejo, J.L.; Rojas-Carvajal, A.M.; Aguilar-Cordero, M.J. Reporting of Perinatal Outcomes in Probiotic Randomized Controlled Trials. A Systematic Review and Meta-Analysis. Nutrients 2021, 13, 256. [https://doi.org/10.3390/nu13010256]
Patrocinador
Spanish Ministry of Science, Innovation, and Universities (Project FIS-ISCIII) P117/02305Resumen
The use of probiotic microorganisms in clinical practice has increased in recent years and a
significant number of pregnant women are regular consumers of these products. However, probiotics
might modulate the immune system, and whether or not this modulation is beneficial for perinatal
outcomes is unclear. We performed a systematic review and meta-analysis to evaluate the reporting
of perinatal outcomes in randomized controlled trials including women supplemented with probiotic
microorganisms during pregnancy. We also analyzed the effects that the administration of probiotic
microorganisms exerts on perinatal outcomes. In the review, 46 papers were included and 25 were
meta-analyzed. Reporting of perinatal outcomes was highly inconsistent across the studies. Only
birth weight, cesarean section, and weeks of gestation were reported in more than 50% of the studies.
Random effects meta-analysis results showed that the administration of probiotic microorganisms
during pregnancy did not have any a positive or negative impact on the perinatal outcomes evaluated.
Subgroup analysis results at the strain level were not significantly different from main analysis results.
The administration of probiotic microorganisms does not appear to influence perinatal outcomes.
Nonetheless, future probiotic studies conducted in pregnant women should report probiotic strains
and perinatal outcomes in order to shed light upon probiotics’ effects on pregnancy outcomes.