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dc.contributor.authorMartín Masot, Rafael
dc.contributor.authorMaldonado Lozano, José
dc.identifier.citationMartín-Masot, R., Mota-Martorell, N., Jové, M., Maldonado, J., Pamplona, R., & Nestares, T. (2020). Alterations in One-Carbon Metabolism in Celiac Disease. Nutrients, 12(12), 3723. [doi:10.3390/nu12123723]es_ES
dc.description.abstractCeliac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating di erences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD.es_ES
dc.description.sponsorshipJunta de Andalucía P12-AGR-2581es_ES
dc.description.sponsorshipSpanish Ministry of Science, Innovation, and Universities (Ministerio de Ciencia, Innovacion y Universidades) RTI2018-099200-BI00es_ES
dc.description.sponsorshipGeneralitat of Catalonia: Agency for Management of University and Research Grants 2017SGR696es_ES
dc.description.sponsorshipDepartment of Health SLT002/16/00250es_ES
dc.description.sponsorshipEuropean Union (EU)es_ES
dc.description.sponsorshipGrant "Investigation grant program by the SPAO" 2020 editiones_ES
dc.rightsAtribución 3.0 España*
dc.subjectAmino acids es_ES
dc.subjectCeliac disease es_ES
dc.subjectFolate cyclees_ES
dc.subjectMass spectrometry es_ES
dc.subjectMethionine cyclees_ES
dc.subjectMethionine savage pathwayes_ES
dc.subjectTranssulfuration pathwayes_ES
dc.titleAlterations in One-Carbon Metabolism in Celiac Diseasees_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España