Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature
Metadatos
Afficher la notice complèteAuteur
Silini, Antonietta Rosa; Abadía Molina, Ana Clara; García Olivares, Enrique Fernando; Ruiz Ruiz, María CarmenEditorial
FRONTIERS MEDIA SA
Materia
Perinatal Derivatives Tissues Placenta Fetal annexes Cells Consensus nomenclature
Date
2020Referencia bibliográfica
Silini AR, Di Pietro R, Lang-Olip I, Alviano F, Banerjee A, Basile M, Borutinskaite V, Eissner G, Gellhaus A, Giebel B, Huang Y-C, Janev A, Kreft ME, Kupper N, Abadía-Molina AC, Olivares EG, Pandolfi A, Papait A, Pozzobon M, Ruiz-Ruiz C, Soritau O, Susman S, Szukiewicz D, Weidinger A, Wolbank S, Huppertz B and Parolini O (2020) Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature. Front. Bioeng. Biotechnol. 8:610544. doi: 10.3389/fbioe.2020.610544
Patrocinador
Austrian Science Fund (FWF) DOC 31-B26; Medical University Graz; Universita Cattolica del Sacro Cuore; PRIN 2017 program of Italian Ministry of Research and University (MIUR) 2017RSAFK7; Ministry of Health, Italy GR-2018-12366992; Slovenian Research Agency - Slovenia P3-0108; MRIC UL IP-0510; Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion; ISCIII Subdireccion General de Evaluacion y Fomento de la Investigacion; Ministerio de Economia y Competitividad, Spain PI16/01642; European Union (EU); European Community (EC); German Research Foundation (DFG) GE-2223/2-1Résumé
Progress in the understanding of the biology of perinatal tissues has contributed to the
breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely
birth-associated tissues, cells, and secreted factors. The significant knowledge acquired
in the past two decades, along with the increasing interest in perinatal derivatives, fuels
an urgent need for the precise identification of PnD and the establishment of updated
consensus criteria policies for their characterization. The aim of this review is not to go into detail on preclinical or clinical trials, but rather we address specific issues
that are relevant for the definition/characterization of perinatal cells, starting from an
understanding of the development of the human placenta, its structure, and the different
cell populations that can be isolated from the different perinatal tissues. We describe
where the cells are located within the placenta and their cell morphology and phenotype.
We also propose nomenclature for the cell populations and derivatives discussed herein.
This review is a joint effort from the COST SPRINT Action (CA17116), which broadly
aims at approaching consensus for different aspects of PnD research, such as providing
inputs for future standards for the processing and in vitro characterization and clinical
application of PnD.