Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease
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Heme oxygenaseGastrointestinal tractCancerDiabetesPancreatitisInflammatory bowel diseasePeptic ulcer diseaseFatty liver diseaseFerroptosis
Puentes-Pardo, J. D., Moreno-SanJuan, S., Carazo, Á., & León, J. (2020). Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease. Antioxidants, 9(12), 1214. [doi:10.3390/antiox9121214]
SponsorshipInstituto de Salud Carlos III European Union (EU) PI18/01947; Nicolas Monardes Program from the Andalusian Health Service C-0033-2015; Ministerio de Ciencia, Innovacion y Universidades (Spain) FPU19/02269
Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent. As many studies suggest, HO-1 is highly expressed in the gastrointestinal tract where it is involved in the response to inflammatory processes, which may lead to several diseases such as pancreatitis, diabetes, fatty liver disease, inflammatory bowel disease, and cancer. In this review, we highlight the pivotal role of HO-1 and its downstream e ectors in the development of disorders and their beneficial e ects on the maintenance of the gastrointestinal tract health. We also examine clinical trials involving the therapeutic targets derived from HO-1 system for the most common diseases of the digestive system.