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dc.contributor.authorRobles Vera, Iñaki 
dc.contributor.authorde la Visitación, Néstor
dc.contributor.authorSánchez, Manuel
dc.contributor.authorGómez Guzmán, Manuel 
dc.contributor.authorJiménez Moleón, Rosario 
dc.contributor.authorMoleón Moya, Javier 
dc.contributor.authorGonzález Correa, Cristina 
dc.contributor.authorRomero Pérez, Miguel 
dc.contributor.authorDuarte Pérez, Juan Manuel 
dc.date.accessioned2021-02-11T09:36:37Z
dc.date.available2021-02-11T09:36:37Z
dc.date.issued2020-11-28
dc.identifier.citationGarcía-García, G., Fernández-Álvarez, F., Cabeza, L., Delgado, Á. V., Melguizo, C., Prados, J. C., & Arias, J. L. (2020). Gemcitabine-Loaded Magnetically Responsive Poly (ε-caprolactone) Nanoparticles against Breast Cancer. Polymers, 12(12), 2790. [doi:10.3390/antiox9121199]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/66458
dc.description.abstractMicrobiota is involved in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzed whether MMF improves dysbiosis in mineralocorticoid-induced hypertension. MaleWistar rats were assigned to three groups: untreated (CTR), deoxycorticosterone acetate (DOCA)-salt, and DOCA treated with MMF for 4 weeks. MMF treatment reduced systolic BP, improved endothelial dysfunction, and reduced oxidative stress and inflammation in aorta. A clear separation in the gut bacterial community between CTR andDOCAgroups was found, whereas the cluster belonging toDOCA-MMF group was found to be intermixed. No changes were found at the phylum level among all experimental groups. MMF restored the elevation in lactate-producing bacteria found in DOCA-salt joined to an increase in the acetate-producing bacteria. MMF restored the percentage of anaerobic bacteria in the DOCA-salt group to values similar to control rats. The improvement of gut dysbiosis was associated with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited neuroinflammation in the paraventricular nuclei in the hypothalamus. This study demonstrates for the first time that MMF reduces gut dysbiosis in DOCA-salt hypertension models. This e ect seems to be related to its capacity to improve gut integrity due to reduced sympathetic drive in the gut associated with reduced brain neuroinflammation.es_ES
dc.description.sponsorshipComisión Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad SAF2017-84894-Res_ES
dc.description.sponsorshipJunta de Andalucía CTS-164es_ES
dc.description.sponsorshipEuropean Union (EU)es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad, Instituto de Salud Carlos III (CIBER-CV), Spaines_ES
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Heart Lung & Blood Institute (NHLBI) HL102033es_ES
dc.description.sponsorshipEuropean Union (Fondo Europeo de Desarrollo Regional, FEDER, "FEDER una manera de hacer Europa")es_ES
dc.language.isoenges_ES
dc.publisherMdpies_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectMycophenolatees_ES
dc.subjectGut dysbiosises_ES
dc.subjectHypertension es_ES
dc.subjectOxidative stress es_ES
dc.subjectInflammation es_ES
dc.subject(Deoxycorticosterone acetate) DOCA-salt modeles_ES
dc.titleMycophenolate Improves Brain–Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/antiox9121199
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España