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dc.contributor.authorMartínez Gómez, Estrella
dc.contributor.authorPérez Carpena, Patricia 
dc.contributor.authorFlook, Marisa
dc.contributor.authorLópez Escámez, José Antonio 
dc.date.accessioned2021-02-09T11:36:41Z
dc.date.available2021-02-09T11:36:41Z
dc.date.issued2020-12-11
dc.identifier.citationMartinez-Gomez, E., Perez-Carpena, P., Flook, M., & Lopez-Escamez, J. A. (2020). A Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Loss. Journal of clinical medicine, 9(12), 4011. [doi:10.3390/jcm9124011]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/66407
dc.description.abstractCongenital cytomegalovirus (CMV) infection induces a clinical syndrome usually associated with hearing loss. However, the e ect of acquired CVM infection in adults and children has not been clearly defined. The objective of this review is to critically appraise scientific evidence regarding the association of acquired CMV infection with postnatal hearing loss or tinnitus. A systematic review of records reporting sensorineural hearing loss (SNHL) or tinnitus and acquired CMV infection including articles published in English was performed. Search strategy was limited to human studies with acquired CMV infection. After screening and quality assessment, nine studies involving 1528 individuals fulfilled the inclusion criteria. A total of 14% of patients with SNHL showed evidence of previous exposure to CMV, while in individuals without SNHL (controls) the percentage rose up to 19.3%. SNHL was reported as unilateral or bilateral in 15.3%, and not specified in 84.7% of cases. The degree of SNHL ranged from mild to profound for both children and adults. None of the records reported tinnitus. The prevalence of children or adults with acquired SNHL with a confirmed acquired CMV infection by Polymerase Chain Reaction (PCR) or IgM anti-CMV antibodies is low. Phenotyping of patients with acquired CMV infection was limited to hearing loss by pure tone audiometry and no additional audiological testing was performed in most of the studies. Additional symptoms deserve more attention, including episodic vertigo or tinnitus, since some patients with the clinical spectrum of Meniere Disease could result from a CMV latent infection.es_ES
dc.description.sponsorshipInstituto de Salud Carlos IIIes_ES
dc.description.sponsorshipEuropean Regional Funds PI17/1644 PE-0356-2018es_ES
dc.description.sponsorship"IN VITRO PRECLINICAL TRIAL AND MONITORIN OF CLINICAL RESPONSE IN PATIENTS WITH MENIERE DISEASE (CLINMON)" from Andalusian Health Government PE-0356-2018es_ES
dc.description.sponsorshipInstituto de Salud Carlos III FI18/00228es_ES
dc.language.isoenges_ES
dc.publisherMdpies_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectCytomegalovirus es_ES
dc.subjectSensorineural hearing losses_ES
dc.subjectTinnituses_ES
dc.subjectSystematic reviewes_ES
dc.titleA Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Losses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/jcm9124011
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España