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dc.contributor.authorTorrecillas-Martínez, Laura
dc.contributor.authorCatena Martínez, Andrés 
dc.contributor.authorO'Valle Ravassa, Francisco Javier 
dc.contributor.authorSolano Galvis, César Augusto 
dc.contributor.authorPadial Molina, Miguel 
dc.contributor.authorGalindo Moreno, Pablo Antonio
dc.identifier.citationTorrecillas-Martínez L, Catena A, O’Valle F, Solano-Galvis C, Padial-Molina M and Galindo-Moreno P (2020) On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model. Front. Hum. Neurosci. 14:558703. [doi: 10.3389/fnhum.2020.558703]es_ES
dc.description.abstractBackground: Pain has been associated with structural changes of the brain. However, evidence regarding white matter changes in response to acute pain protocols is still scarce. In the present study, we assess the existence of differences in brain white matter related to pain intensity reported by patients undergoing surgical removal of a mandibular impacted third molar using diffusion tensor imaging (DTI) analysis. Methods: 30 participants reported their subjective pain using a visual analog scale at three postsurgical stages: under anesthesia, in pain, and after the administration of an analgesic. The diffusion data were acquired prior to surgery. Results: DTI analysis yielded significant positive associations of fractional anisotropy in white matter areas related to pain processing (corticospinal tract, corona radiata, corpus callosum) with the differences in pain between the three postsurgery stages. Extent and location of these associations depended on the magnitude of the subjective pain differences. Tractography analysis indicated that some pain–tract associations are significant only when pain stage is involved in the contrast (posterior corona radiata), while others (middle cerebellar peduncle, pontine crossing) are only when anesthesia is involved in the contrast. Conclusions: The association of white matter fractional anisotropy and connectivity, measured before the pain stages, with subjective pain depends on the magnitude of the differences in pain scores.es_ES
dc.description.sponsorshipJunta de Andalucía CTS-138 CTS-176 CTS-1028es_ES
dc.description.sponsorshipTalentia Scholarship Program of the Regional Ministry for Innovation, Science, and Enterprise (Junta de Andalucía)es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness PSI2012-39292es_ES
dc.description.sponsorshipAndalucia Talent Hub Program from the Andalusian Knowledge Agencyes_ES
dc.description.sponsorshipEuropean Union (EU) 291780es_ES
dc.description.sponsorshipMinistry of Economy, Innovation, Science and Employment of the Junta de Andaluciaes_ES
dc.publisherFrontiers Media SAes_ES
dc.rightsAtribución 3.0 España*
dc.subjectAnesthesia es_ES
dc.subjectAcute paines_ES
dc.subjectFractional anisotropyes_ES
dc.subjectWhite matter structurees_ES
dc.titleOn the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Modeles_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España