Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment (PROTECT) of Hydroxychloroquine, Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID-19 infection who have no comorbidities like diabetes mellitus: A structured summary of a study protocol for a randomized controlled trial
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BMC
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COVID-19 Randomised controlled trial Protocol SARS-CoV-2 Hydroxychloroquine Azithromycin Oseltamivir Multi-center Adaptive Randomization
Date
2020Referencia bibliográfica
Akram, J., Azhar, S., Shahzad, M. et al. Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment (PROTECT) of Hydroxychloroquine, Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID-19 infection who have no comorbidities like diabetes mellitus: A structured summary of a study protocol for a randomized controlled trial. Trials 21, 702 (2020). https://doi.org/10.1186/s13063-020-04616-4
Sponsorship
University of Health Sciences (UHS) Lahore, Punjab, PakistanAbstract
Objectives: To evaluate the effectiveness of Hydroxychloroquine Phosphate/Sulfate (200 mg orally 8 hourly thrice a
day for 5 days), versus oseltamivir (75 mg orally twice a day for 5 days), and versus Azithromycin (500 mg orally daily
on day 1, followed by 250 mg orally twice a day on days 2-5) alone and in combination (in all seven groups), in
clearing the coronavirus (COVID-19) nucleic acid from throat and nasal swab and in bringing about clinical
improvement on day 7 of follow-up (primary outcomes).