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dc.contributor.authorRubio Roldan, Alejandro
dc.contributor.authorPeris, Guillermo
dc.contributor.authorSánchez, Laura
dc.contributor.authorTristán Ramos, Pablo
dc.contributor.authorAmador Cubero, Suyapa
dc.contributor.authorRodríguez Heras, Sara
dc.identifier.citationTristán-Ramos, P., Rubio-Roldan, A., Peris, G., Sánchez, L., Amador-Cubero, S., Viollet, S., ... & Heras, S. R. (2020). The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition. Nature communications, 11(1), 1-14. [doi:10.1038/s41467-020-19430-4]es_ES
dc.description.abstractNearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed and mobilized in different cancers, generating mutagenic insertions that could affect tumor malignancy. Tumor suppressor microRNAs are ∼22nt RNAs that post-transcriptionally regulate oncogene expression and are frequently downregulated in cancer. Here we explore whether they also influence L1 mobilization. We show that downregulation of let-7 correlates with accumulation of L1 insertions in human lung cancer. Furthermore, we demonstrate that let-7 binds to the L1 mRNA and impairs the translation of the second L1-encoded protein, ORF2p, reducing its mobilization. Overall, our data reveals that let-7, one of the most relevant microRNAs, maintains somatic genome integrity by restricting L1 retrotransposition.es_ES
dc.description.sponsorshipEuropean Research Council (ERC) ERC-2009-StG 243312es_ES
dc.description.sponsorshipFrench National Research Agency (ANR) ANR-11-LABX-0028-01 ANR-15-IDEX-01es_ES
dc.description.sponsorshipCentre National de la Recherche Scientifique (CNRS) 3546es_ES
dc.description.sponsorshipUniversity Hospital Federation (FHU) OncoAgees_ES
dc.description.sponsorshipMINECO PEJ-2014-A-31985 SAF2015-71589-Pes_ES
dc.description.sponsorshipMINECO by European Regional Development Fund SAF2015-71589-Pes_ES
dc.description.sponsorshipSpanish Government RYC-2016-21395es_ES
dc.description.sponsorshipCareer Integration Grant-Marie Curie FP7-PEOPLE-2011-CIG-303812es_ES
dc.publisherNature Researches_ES
dc.rightsAtribución 3.0 España*
dc.titleThe tumor suppressor microRNA let-7 inhibits human LINE-1 retrotranspositiones_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España