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dc.contributor.authorMora Boza, Ana
dc.contributor.authorLópez Ruiz, Elena
dc.contributor.authorJiménez, Gema
dc.contributor.authorMarchal Corrales, Juan Antonio 
dc.date.accessioned2021-01-20T10:51:55Z
dc.date.available2021-01-20T10:51:55Z
dc.date.issued2020-11-11
dc.identifier.citationMora-Boza, A., López-Ruiz, E., López-Donaire, M. L., Jiménez, G., Aguilar, M. R., Marchal, J. A., ... & Gálvez-Martín, P. (2020). Evaluation of Glycerylphytate Crosslinked Semi-and Interpenetrated Polymer Membranes of Hyaluronic Acid and Chitosan for Tissue Engineering. Polymers, 12(11), 2661. [doi:10.3390/polym1211266]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/65577
dc.description.abstractIn the present study, semi- and interpenetrated polymer network (IPN) systems based on hyaluronic acid (HA) and chitosan using ionic crosslinking of chitosan with a bioactive crosslinker, glycerylphytate (G1Phy), and UV irradiation of methacrylate were developed, characterized and evaluated as potential supports for tissue engineering. Semi- and IPN systems showed significant di erences between them regarding composition, morphology, and mechanical properties after physicochemical characterization. Dual crosslinking process of IPN systems enhanced HA retention and mechanical properties, providing also flatter and denser surfaces in comparison to semi-IPN membranes. The biological performance was evaluated on primary human mesenchymal stem cells (hMSCs) and the systems revealed no cytotoxic e ect. The excellent biocompatibility of the systems was demonstrated by large spreading areas of hMSCs on hydrogel membrane surfaces. Cell proliferation increased over time for all the systems, being significantly enhanced in the semi-IPN, which suggested that these polymeric membranes could be proposed as an e ective promoter system of tissue repair. In this sense, the developed crosslinked biomimetic and biodegradable membranes can provide a stable and amenable environment for hMSCs support and growth with potential applications in the biomedical field.es_ES
dc.description.sponsorshipLa Caixa Foundation 100010434 LCF/BQ/ES16/11570018es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness RTC-2016-5451-1es_ES
dc.description.sponsorshipInstituto de Salud Carlos III FMM-AP17196-2019es_ES
dc.language.isoenges_ES
dc.publisherMdpies_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectInterpenetrated polymer networkes_ES
dc.subjectSemi-IPNes_ES
dc.subjectMethacrylated hyaluronic acides_ES
dc.subjectChitosanes_ES
dc.subjectGlycerylphytatees_ES
dc.subjectHuman Mesenchymal Stem Cellses_ES
dc.titleEvaluation of Glycerylphytate Crosslinked Semi- and Interpenetrated Polymer Membranes of Hyaluronic Acid and Chitosan for Tissue Engineeringes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/polym12112661
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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