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dc.contributor.authorGómez Llorente, Mª Amelia 
dc.contributor.authorMartínez Cañavate, Ana
dc.contributor.authorChueca Porcuna, Natalia
dc.contributor.authorRico Prados, María Cruz
dc.contributor.authorRomero, Raquel
dc.contributor.authorMorillo, José Antonio
dc.contributor.authorCamacho Páez, José 
dc.contributor.authorGómez Llorente, Carolina 
dc.date.accessioned2020-12-15T13:15:58Z
dc.date.available2020-12-15T13:15:58Z
dc.date.issued2020-09-18
dc.identifier.citationGomez-Llorente, M., Martínez-Cañavate, A., Chueca, N., Rico, M., Romero, R., Anguita-Ruiz, A., ... & Morillo, J. A. (2020). A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children. Biomedicines, 8(9), 359. [doi:10.3390/biomedicines8090359]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/64927
dc.description.abstractAsthma is a multifactorial condition where patients with identical clinical diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is reflected in the definition of two main endotypes. We aimed to explore the metabolic and microbiota signatures that characterize the clinical allergic asthma phenotype in obese children. Methods: We used a multi-omics approach combining clinical data, plasma and fecal inflammatory biomarkers, metagenomics, and metabolomics data in a cohort of allergic asthmatic children. Results: We observed that the obese allergic asthmatic phenotype was markedly associated with higher levels of leptin and lower relative proportions of plasma acetate and a member from the Clostridiales order. Moreover, allergic children with a worse asthma outcome showed higher levels of large unstained cells, fecal D lactate and D/L lactate ratio, and with a higher relative proportion of plasma creatinine and an unclassified family member from the RF39 order belonging to the Mollicutes class. Otherwise, children with persistent asthma presented lower levels of plasma citrate and dimethylsulfone. Conclusion: Our integrative approach shows the molecular heterogeneity of the allergic asthma phenotype while highlighting the use of omics technologies to examine the clinical phenotype at a more holistic level.es_ES
dc.description.sponsorshipFundación Progreso y Salud Project PI-0373-2014es_ES
dc.description.sponsorshipRedes temáticas de investigación cooperativa RETIC Red SAMID RD12/0026/0015es_ES
dc.language.isoenges_ES
dc.publisherMdpies_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAsthma es_ES
dc.subjectGastrointestinal microbiomees_ES
dc.subjectMetabolomicses_ES
dc.subjectMulti-omics approaches_ES
dc.titleA Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Childrenes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/biomedicines8090359
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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