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dc.contributor.authorGonzález-Alonso, Adrián
dc.contributor.authorVarela Lopez, Alfonso
dc.contributor.authorRamírez Tortosa, María Carmen
dc.contributor.authorOchoa Herrera, Julio José
dc.contributor.authorQuiles Morales, José Luis
dc.identifier.citationGonzález-Alonso, A., Ramírez-Tortosa, C. L., Varela-López, A., Roche, E., Arribas, M. I., Ramírez-Tortosa, M. C., ... & Quiles, J. L. (2015). Sunflower oil but not fish oil resembles positive effects of virgin olive oil on aged pancreas after life-long coenzyme Q addition. International journal of molecular sciences, 16(10), 23425-23445. [DOI: 10.3390/ijms161023425]es_ES
dc.description.abstractAn adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related pancreatic disorders. In this context, it has been reported that different pancreatic compartments from rats were affected according to the fat composition consumed. Since there is a close relationship between mitochondria, oxidative stress and aging, an experimental approach has been developed to gain more insight into this process in the pancreas. A low dosage of coenzyme Q was administered life-long in rats in order to try to prevent pancreatic aging-related alterations associated to some dietary fat sources. According to that, three groups of rats were fed normocaloric diets containing Coenzyme Q (CoQ) for two years, where virgin olive, sunflower, or fish oil was included as unique fat source. Pancreatic samples for microscopy and blood samples were collected at the moment of euthanasia. The main finding is that CoQ supplementation gives different results according to fat used in diet. When sunflower oil was the main fat in the diet, CoQ supplementation seems to improve endocrine pancreas structure and in particular β-cell mass resembling positive effects of virgin olive oil. Conversely, CoQ intake does not seem to improve the structural alterations of exocrine compartment previously observed in fish oil fed rats. Therefore CoQ may improve pancreatic alterations associated to the chronic intake of some dietary fat sources.es_ES
dc.description.sponsorshipSpanish Government AGL2008-01057es_ES
dc.description.sponsorshipAutonomous Government of Andalucia AGR832es_ES
dc.description.sponsorshipGerman Research Foundation (DFG)es_ES
dc.description.sponsorshipGeneralitat Valenciana APOSTD/2012/021es_ES
dc.rightsAtribución 3.0 España*
dc.subjectEndocrine pancreases_ES
dc.subjectExocrine pancreases_ES
dc.subjectPancreatic aginges_ES
dc.subjectPancreatic fibrosis of the elderlyes_ES
dc.subjectDietary lipidses_ES
dc.titleSunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Additiones_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España