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dc.contributor.authorGarcía Villén, Fátima
dc.contributor.authorSánchez Espejo, Rita
dc.contributor.authorBorrego Sánchez, Ana
dc.contributor.authorViseras, César
dc.identifier.citationGarcía-Villén, F., Sánchez-Espejo, R., Borrego-Sánchez, A., Cerezo, P., Cucca, L., Sandri, G., & Viseras, C. (2020). Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels. Pharmaceutics, 12(9), 891. [doi:10.3390/pharmaceutics12090891]es_ES
dc.description.abstractInorganic hydrogels formulated with spring waters and clay minerals are used to treat musculoskeletal disorders and skin a ections. Their underlying mechanism of action for skin disorders is not clear, although it is usually ascribed to the chemical composition of the formulation. The aim of this study was to assess the composition and in vitro release of elements with potential wound healing e ects from hydrogels prepared with two nanoclays and natural spring water. In vitro Franz cell studies were used and the element concentration was measured by inductively coupled plasma techniques. Biocompatibility studies were used to evaluate the potential toxicity of the formulation against fibroblasts. The studied hydrogels released elements with known therapeutic interest in wound healing. The released ratios of some elements, such as Mg:Ca or Zn:Ca, played a significant role in the final therapeutic activity of the formulation. In particular, the proliferative activity of fibroblasts was ascribed to the release of Mn and the Zn:Ca ratio. Moreover, the importance of formulative studies is highlighted, since it is the optimal combination of the correct ingredients that makes a formulation e ective.es_ES
dc.description.sponsorshipInstituto de Salud Carlos III Spanish Government CGL2016-80833-Res_ES
dc.description.sponsorshipJunta de Andalucía P18-RT-3786es_ES
dc.description.sponsorshipMinisterio de Educación, Cultura y Deporte FPU15/01577es_ES
dc.rightsAtribución 3.0 España*
dc.subjectSpring wateres_ES
dc.subjectWound healinges_ES
dc.subjectFranz celles_ES
dc.subjectBioactive elementses_ES
dc.titleCorrelation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogelses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España