Improvement of mesoporous silica nanoparticles: a new approach in the administration of NSAIDs

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) constitute a heterogeneous group of compounds that exhibit analgesic, anti-inflammatory and antipyretic activity. However, the GI damage produced by NSAIDs has been widely studied. Thus, the aim of the present study was the development of mesoporous silica nanoparticles in order to increase the capacity of drug transport, emphasizing those with low solubility such as NSAIDs. The morphology and structure characteristics of the synthesized nanoparticles were studied by transmission electron microscopy (TEM), besides, its particle size, surface charge, specific area and cell viability will be determined. The analytical application of mesoporous silica nanoparticles as ibuprofen carrier was also evaluated by measuring their drug loading characteristics and release behavior. The results showed that the synthesized NPs had efficient physicochemical characteristics, high EE%, low toxicity, and controlled ibuprofen release.