Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage
Metadatos
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MDPI
Materia
Skin damage UVA-radiation ROS Apoptosis Mitochondria functionality Antioxidant defense Inflammatory status Strawberry polyphenols Cosmetic formulation
Fecha
2017Referencia bibliográfica
Gasparrini, M.; Forbes-Hernandez, T.Y.; Afrin, S.; Reboredo-Rodriguez, P.; Cianciosi, D.; Mezzetti, B.; Quiles, J.L.; Bompadre, S.; Battino, M.; Giampieri, F. Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. Nutrients 2017, 9, 605. [https://doi.org/10.3390/nu9060605]
Resumen
Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated
production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading
to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways,
responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use
of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic
tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present
work was to test the efficacy of strawberry (50 µg/mL)-based formulations supplemented with
Coenzyme Q10 (100 µg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated
with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS)
production, the expression of proteins involved in antioxidant and inflammatory response, and
mitochondrial functionality were evaluated. The results showed that the synergic topical use of
strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell
death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving
mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations
as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases
in order to decrease or substitute the amount of synthetic sunscreen agents.