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dc.contributor.authorAouichat, Samira
dc.contributor.authorChayah, Meriem
dc.contributor.authorBouguerra-Aouichat, Souhila
dc.contributor.authorAgil Abdalla, Mhmad Ahmad
dc.identifier.citationAouichat, S.; Chayah, M.; Bouguerra-Aouichat, S.; Agil, A. Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue. Nutrients 2020, 12, 2185. [doi:10.3390/nu12082185]es_ES
dc.descriptionWe would like to express our appreciation to all staff from Diabesity-UGR group (AnaTorrices, DiegoSalagre, and Juan Miguel Leiva) for their technical support and for being attentive to answer our research questions and to AsmaAmalou from Physiopathology-USTHB group for the animal sacrifice assistance. We would also like to express our warmest thanks to NemchaLebaili and her staff from ÉcoleNormaleSupérieure (Kouba, Algiers) for the use of their animal facilities.es_ES
dc.descriptionThe following are available online at, Table S1: normal chow and cafeteria food items compositions as given by the product manufacturers.es_ES
dc.description.abstractTime-restricted feeding (TRF) showed a potent effect in preventing obesity and improving metabolicoutcomes in several animal models of obesity. However, there is, as of yet, scarce evidence concerning its effectiveness against obesogenic challenges that more accurately mimic human Western diets, such as the cafeteria diet. Moreover, the mechanism for its efficacy is poorly understood. White adipose browning has been linked to body weight loss. Herein, we tested whether TRF has the potential to induce browning of inguinal white adipose tissue (iWAT) and to attenuate obesity and associated dyslipidemia in a cafeteria-diet-induced obesity model. Male Wistar rats were fed normal laboratory chow (NC) or cafeteria diet (CAF) for 16 weeks and were subdivided into two groups that were subjected to either ad libitum (ad lib, A) or TRF (R) for 8 h per day. Rats under the TRF regimen had a lower body weight gain and adiposity than the diet-matchedad lib rats, despite equivalent levels of food intake and locomotor activity. In addition, TRF improved the deranged lipid profile (total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c)) and atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), coronary risk index (CRI) in CAF-fed rats. Remarkably, TRF resulted in decreased size of adipocytes and induced emergence of multilocular brown-like adipocytes in iWAT of NC- and CAF-fed rats. Protein expression of browning markers, such as uncoupling protein-1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), were also up-regulated in the iWAToftime-restricted NC- or CAF-fed rats. These findings suggest that a TRF regimen is an effective strategy to improve CAF diet-induced obesity, probably via a mechanismthe involving WAT browning process.es_ES
dc.description.sponsorshipMinisterio de Economia y Competitividad (Spain) SAF2016-79794-Res_ES
dc.description.sponsorshipErasmus + Mobility Program Dimension Internacional from "European Commission" KA 107es_ES
dc.rightsAtribución 3.0 España*
dc.subjectTime-restricted feedinges_ES
dc.subjectCafeteria dietes_ES
dc.subjectObesity es_ES
dc.subjectLipid profileses_ES
dc.subjectAtherogenic indiceses_ES
dc.subjectWhite adipose tissue browninges_ES
dc.titleTime-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissuees_ES

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Atribución 3.0 España
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