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dc.contributor.authorGiaccherini, Matteo
dc.contributor.authorSáinz Pérez, Juan
dc.contributor.authorSánchez Maldonado, José Manuel
dc.contributor.authorJurado, Manuel
dc.contributor.authorHernández Mohedo, Francisca
dc.date.accessioned2020-11-20T12:28:24Z
dc.date.available2020-11-20T12:28:24Z
dc.date.issued2020-09-01
dc.identifier.citationGiaccherini, M., Macauda, A., Sgherza, N., Sainz, J., Gemignani, F., Maldonado, J. M. S., ... & Góra-Tybor, J. (2020). Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms. Blood Cancer Journal, 10(8), 1-7. [DOI: 10.1038/s41408-020-00356-5]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/64410
dc.descriptionD.C., F.C., and M.G. conceived and designed the study. A.M. and M.G. performed labwork. A.M., F.C., D.C., and M.G. drafted the manuscript. A.M., F.C., D.C., and M.G. performed data quality control and statistical analyses. All other authors provided samples and data. All authors critically read, commented, and approved the manuscript.es_ES
dc.description.abstractTelomere length measured in leukocyte (LTL) has been found to be associated with the risk of developing several cancer types, including myeloproliferative neoplasms (MPNs). LTL is genetically determined by, at least, 11 SNPs previously shown to influence LTL. Their combination in a score has been used as a genetic instrument to measure LTL and evaluate the causative association between LTL and the risk of several cancer types. We tested, for the first time, the “teloscore” in 480 MPN patients and 909 healthy controls in a European multi-center case–control study. We found an increased risk to develop MPNs with longer genetically determined telomeres (OR = 1.82, 95% CI 1.24–2.68, P = 2.21 × 10−3, comparing the highest with the lowest quintile of the teloscore distribution). Analyzing the SNPs individually we confirm the association between TERT-rs2736100-C allele and increased risk of developing MPNs and we report a novel association of the OBFC1-rs9420907-C variant with higher MPN risk (ORallelic= 1.43; 95% CI 1.15–1.77; P = 1.35 × 10−3). Consistently with the results obtained with the teloscore, both risk alleles are also associated with longer LTL. In conclusion, our results suggest that genetically determined longer telomeres could be a risk marker for MPN developmentes_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleGenetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasmses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41408-020-00356-5
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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