Evaluating the Oxidative Stress in Inflammation: Role of Melatonin
Metadatos
Mostrar el registro completo del ítemEditorial
Mpdi
Materia
Antioxidants Melatonin Oxidative stress Inflammation Chronic diseases
Fecha
2015-07-27Referencia bibliográfica
Sánchez, A., Calpena, A. C., & Clares, B. (2015). Evaluating the oxidative stress in inflammation: role of melatonin. International journal of molecular sciences, 16(8), 16981-17004. [https://doi.org/10.3390/ijms160816981]
Resumen
Oxygen is used by eukaryotic cells for metabolic transformations and energy
production in mitochondria. Under physiological conditions, there is a constant endogenous
production of intermediates of reactive oxygen (ROI) and nitrogen species (RNI) that
interact as signaling molecules in physiological mechanisms. When these species are not
eliminated by antioxidants or are produced in excess, oxidative stress arises. Oxidative stress
can damage proteins, lipids, DNA, and organelles. It is a process directly linked to inflammation;
in fact, inflammatory cells secrete a large number of cytokines and chemokines responsible for
the production of ROI and RNI in phagocytic and nonphagocytic cells through the activation
of protein kinases signaling. Currently, there is a wide variety of diseases capable of
producing inflammatory manifestations. While, in the short term, most of these diseases are
not fatal they have a major impact on life quality. Since there is a direct relationship between
chronic inflammation and many emerging disorders like cancer, oral diseases, kidney
diseases, fibromyalgia, gastrointestinal chronic diseases or rheumatics diseases, the aim of
this review is to describe the use and role of melatonin, a hormone secreted by the pineal
gland, that works directly and indirectly as a free radical scavenger, like a potent antioxidant.