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dc.contributor.authorBonel Pérez, Gloria C. B
dc.contributor.authorPérez Jiménez, Amalia 
dc.contributor.authorGris Cárdenas, Isabel
dc.contributor.authorParra Pérez, Alberto M.
dc.contributor.authorLupiáñez Cara, José Antonio 
dc.contributor.authorReyes Zurita, Fernando Jesús 
dc.contributor.authorRufino Palomares, Eva 
dc.date.accessioned2020-11-13T08:51:00Z
dc.date.available2020-11-13T08:51:00Z
dc.date.issued2020
dc.identifier.citationBonel-Pérez, Gloria C.; Pérez-Jiménez, Amalia; Gris-Cárdenas, Isabel; Parra-Pérez, Alberto M.; Lupiáñez, José A.; Reyes-Zurita, Fernando J.; Siles, Eva; Csuk, René; Peragón, Juan; Rufino-Palomares, Eva E. 2020. "Antiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0/G1 Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathway." Molecules 25, no. 18: 4254. [doi: 10.3390/molecules25184254]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/64245
dc.description.abstractNatural products have a significant role in the development of new drugs, being relevant the pentacyclic triterpenes extracted from Olea europaea L. Anticancer effect of uvaol, a natural triterpene, has been scarcely studied. The aim of this study was to understand the anticancer mechanism of uvaol in the HepG2 cell line. Cytotoxicity results showed a selectivity effect of uvaol with higher influence in HepG2 than WRL68 cells used as control. Our results show that uvaol has a clear and selective anticancer activity in HepG2 cells supported by a significant anti-migratory capacity and a significant increase in the expression of HSP-60. Furthermore, the administration of this triterpene induces cell arrest in the G0/G1 phase, as well as an increase in the rate of cell apoptosis. These results are supported by a decrease in the expression of the anti-apoptotic protein Bcl2, an increase in the expression of the pro-apoptotic protein Bax, together with a down-regulation of the AKT/PI3K signaling pathway. A reduction in reactive oxygen species (ROS) levels in HepG2 cells was also observed. Altogether, results showed anti-proliferative and pro-apoptotic effect of uvaol on hepatocellular carcinoma, constituting an interesting challenge in the development of new treatments against this type of cancer.es_ES
dc.description.sponsorshipResearch Plan, Action 7 of University of Jaen, Spain UJA2014/07/13es_ES
dc.description.sponsorshipGeneral Secretariat of Universities, Research and Technology of the Ministry of Economy, Innovation, Science and Employmentes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAKT/PI3K signaling pathwayes_ES
dc.subjectApoptosises_ES
dc.subjectHuman hepatocarcinoma HepG2 cellses_ES
dc.subjectMigration activityes_ES
dc.subjectProliferationes_ES
dc.subjectOxidative stress es_ES
dc.subjectROS levelses_ES
dc.subjectUvaoles_ES
dc.titleAntiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0/G1 Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathwayes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/molecules25184254


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