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Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
dc.contributor.author | Hecel, Aleksandra | |
dc.contributor.author | Domínguez Martín, Alicia | |
dc.date.accessioned | 2020-11-12T11:34:32Z | |
dc.date.available | 2020-11-12T11:34:32Z | |
dc.date.issued | 2020-09-01 | |
dc.identifier.citation | Hecel, A.; Ostrowska, M.; Stokowa-Sołtys, K.; Wątły, J.; Dudek, D.; Miller, A.; Potocki, S.; Matera-Witkiewicz, A.; Dominguez-Martin, A.; Kozłowski, H.; Rowińska-Żyrek, M. Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19? Pharmaceuticals 2020, 13, 228. [doi:10.3390/ph13090228] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/64223 | |
dc.description | The authors would like to thank Agnieszka Michalczuk for providing us with her artistic vision of SARS-CoV-2. | es_ES |
dc.description.abstract | Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics. | es_ES |
dc.description.sponsorship | National Science Center, Poland UMO-2017/26/A/ST5/00363 UMO-2017/26/A/ST5/00364 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | COVID-19 | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | 2019-nCoV | es_ES |
dc.subject | Zn(II) ionophores | es_ES |
dc.subject | Chloroquine | es_ES |
dc.subject | Hydroxychloroquine | es_ES |
dc.title | Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19? | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/ph13090228 | |
dc.type.hasVersion | VoR | es_ES |