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dc.contributor.authorJiménez Fernández, Sara
dc.contributor.authorGurpegui Fernández De Legaria, Manuel 
dc.contributor.authorGarrote Rojas, Daniel 
dc.contributor.authorGutiérrez Rojas, Luis 
dc.contributor.authorCarretero, María D.
dc.contributor.authorCorrell, Christoph U.
dc.date.accessioned2020-11-06T10:32:11Z
dc.date.available2020-11-06T10:32:11Z
dc.date.issued2020-09
dc.identifier.citationJiménez‐Fernández, S., Gurpegui, M., Garrote‐Rojas, D. A., Gutiérrez‐Rojas, L., Carretero, M. D., & Correll, C. U. (2020). Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta‐analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls. Bipolar Disorders. [doi:10.1111/bdi.12980]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/64100
dc.description.abstractAbstract Objective: To investigate oxidative stress markers and antioxidants in bipolar disorder (BD). Methods: Electronic MEDLINE/PubMed/Cochrane-Library/Scopus/TripDatabase search until 06/30/2019 for studies comparing antioxidant or oxidative stress markers between BD and healthy controls (HCs). Standardized mean differences (SMD) and 95% confidence intervals (CIs) were calculated for ≥3 studies. Results: Forty-four studies (n = 3,767: BD = 1,979; HCs = 1,788) reported on oxidative stress markers malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS), and total nitrites; antioxidants glutathione (GSH), uric acid, and zinc; or antioxidantenhancing enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and GSH-transferase (GST). Compared with HCs, BD was associated with higher GST (P = .01), CAT (P = .02), nitrites (P < .0001), TBARS (P < .0001), MDA (P = .01), uric acid (P < .0001), and lower GSH (P = .006), without differences in SOD, GPX, and zinc. Compared to HCs, levels were higher in BD-mania for TBARS (P < .0001) and uric acid (P < .0001); in BD-depression for TBARS (P = .02); and BD-euthymia for uric acid (P = .03). Uric acid levels were higher in BD-mania vs BD-depression (P = .002), but not vs BD euthymia. TBARS did not differ between BD-mania and BD-depression. Medication-free BD-mania patients had higher SOD (P = .02) and lower GPX (P < .0001) than HCs. After treatment, BD did not differ from HCs regarding SOD and GPX. Conclusions: Beyond a single biomarker of oxidative stress, the combination of several parameters appears to be more informative for BD in general and taking into account illness polarity. BD is associated with an imbalance in oxidative stress with some phase-specificity for uric acid and TBARS and possible treatment benefits for SOD and GPX. Future studies should take into account confounding factors that can modify oxidative stress status and simultaneously measure oxidative stress markers and antioxidants including different blood sources.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectAntioxidants es_ES
dc.subjectBipolar disorderses_ES
dc.subjectMeta-analysises_ES
dc.subjectOxidative stress es_ES
dc.subjectPolarityes_ES
dc.titleOxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controlses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1111/bdi.12980
dc.type.hasVersionVoRes_ES


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